Tendencies and Challenges in Worldwide Scientific Research on Probiotics.

The central goal of this study was to analyze scientific trends in the research on probiotics, including the number of papers, funding, country collaborations, and most cited publications. The study makes use of bibliometric and social network analysis of papers included in the Science Citation Index Expanded from the Web of Science database. A total of 7221 papers were retrieved, from which 64% were funded papers. Papers were published in journals covering several areas, such as Food Science & Technology, Microbiology, Biotechnology and Applied Microbiology, Nutrition & Dietetics and Agriculture, and Dairy & Animal Science. Coword analysis shows the relationships between microorganisms, diseases, physiological phenomena, and other key words related to food, population, or type of study. The USA appeared as the world leader in the number of articles produced (n = 919), followed by China (n = 689), India (n = 633), and Brazil (n = 506). The most cited papers related to the consensus on the scope and appropriate use of the term probiotic, its effects on the prevention and treatment of some intestinal diseases, its effects on the suppression of immune disorders, the role of probiotics and prebiotics in obesity, the assessment of psychotropic-like properties, and the application for type 2 diabetes.