Literature DB >> 31528696

Tafazzin modulates cellular phospholipid composition to regulate AML stemness.

Ayesh K Seneviratne1,2, Mingjing Xu1, Aaron D Schimmer1,2,3.   

Abstract

Tafazzin is a mitochondrial enzyme necessary for the remodeling of the phospholipid cardiolipin. Seneviratne and Xu et al. demonstrated that Tafazzin-mediated phospholipid production regulates stemness in Acute Myeloid Leukemia (AML). Tafazzin influenced intracellular levels of phospholipids to control AML stemness. Thus, inhibiting mitochondrial phospholipid production could be a new therapeutic strategy for AML.

Entities:  

Keywords:  Tafazzin; acute myeloid leukemia; cancer stem cells; differentiation; leukemia stem cells; mitochondria; phosphatidylserine; phosphatidylserine decarboxylase

Year:  2019        PMID： 31528696      PMCID： PMC6736150          DOI： 10.1080/23723556.2019.1620051

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids.

Authors:  Ayesh K Seneviratne; Mingjing Xu; Juan J Aristizabal Henao; Val A Fajardo; Zhenyue Hao; Veronique Voisin; G Wei Xu; Rose Hurren; S Kim; Neil MacLean; Xiaoming Wang; Marcela Gronda; Danny Jeyaraju; Yulia Jitkova; Troy Ketela; Michael Mullokandov; David Sharon; Geethu Thomas; Raphaël Chouinard-Watkins; James R Hawley; Caitlin Schafer; Helen Loo Yau; Zaza Khuchua; Ahmed Aman; Rima Al-Awar; Atan Gross; Steven M Claypool; Richard P Bazinet; Mathieu Lupien; Steven Chan; Daniel D De Carvalho; Mark D Minden; Gary D Bader; Ken D Stark; Paul LeBlanc; Aaron D Schimmer
Journal:  Cell Stem Cell       Date:  2019-03-28       Impact factor: 24.633

2.  Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Authors:  Courtney L Jones; Brett M Stevens; Angelo D'Alessandro; Julie A Reisz; Rachel Culp-Hill; Travis Nemkov; Shanshan Pei; Nabilah Khan; Biniam Adane; Haobin Ye; Anna Krug; Dominik Reinhold; Clayton Smith; James DeGregori; Daniel A Pollyea; Craig T Jordan
Journal:  Cancer Cell       Date:  2018-11-12       Impact factor: 31.743

3.  Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.

Authors:  Daniel A Pollyea; Brett M Stevens; Courtney L Jones; Amanda Winters; Shanshan Pei; Mohammad Minhajuddin; Angelo D'Alessandro; Rachel Culp-Hill; Kent A Riemondy; Austin E Gillen; Jay R Hesselberth; Diana Abbott; Derek Schatz; Jonathan A Gutman; Enkhtsetseg Purev; Clayton Smith; Craig T Jordan
Journal:  Nat Med       Date:  2018-11-12       Impact factor: 53.440

4.  Characterization of Plasmodium phosphatidylserine decarboxylase expressed in yeast and application for inhibitor screening.

Authors:  Vidya Kumar; Niseema Pachikara; Aprajita Garg; Jae-Yeon Choi; Lauren Lawres; Justin Y Toh; Dennis R Voelker; Choukri Ben Mamoun
Journal:  Mol Microbiol       Date:  2015-12-22       Impact factor: 3.501

5.  Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia.

Authors:  Eytan M Stein; Courtney D DiNardo; Daniel A Pollyea; Amir T Fathi; Gail J Roboz; Jessica K Altman; Richard M Stone; Daniel J DeAngelo; Ross L Levine; Ian W Flinn; Hagop M Kantarjian; Robert Collins; Manish R Patel; Arthur E Frankel; Anthony Stein; Mikkael A Sekeres; Ronan T Swords; Bruno C Medeiros; Christophe Willekens; Paresh Vyas; Alessandra Tosolini; Qiang Xu; Robert D Knight; Katharine E Yen; Sam Agresta; Stephane de Botton; Martin S Tallman
Journal:  Blood       Date:  2017-06-06       Impact factor: 25.476

Review 6.  Disorders of phospholipid metabolism: an emerging class of mitochondrial disease due to defects in nuclear genes.

Authors:  Ya-Wen Lu; Steven M Claypool
Journal:  Front Genet       Date:  2015-02-03       Impact factor: 4.599

7.  A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses.

Authors:  Marielle S Köberlin; Berend Snijder; Leonhard X Heinz; Christoph L Baumann; Astrid Fauster; Gregory I Vladimer; Anne-Claude Gavin; Giulio Superti-Furga
Journal:  Cell       Date:  2015-06-18       Impact factor: 41.582

8.  Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.

Authors:  Fang Wang; Jeremy Travins; Byron DeLaBarre; Virginie Penard-Lacronique; Stefanie Schalm; Erica Hansen; Kimberly Straley; Andrew Kernytsky; Wei Liu; Camelia Gliser; Hua Yang; Stefan Gross; Erin Artin; Veronique Saada; Elena Mylonas; Cyril Quivoron; Janeta Popovici-Muller; Jeffrey O Saunders; Francesco G Salituro; Shunqi Yan; Stuart Murray; Wentao Wei; Yi Gao; Lenny Dang; Marion Dorsch; Sam Agresta; David P Schenkein; Scott A Biller; Shinsan M Su; Stephane de Botton; Katharine E Yen
Journal:  Science       Date:  2013-04-04       Impact factor: 63.714

9.  Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells.

Authors:  Elodie M Kuntz; Pablo Baquero; Alison M Michie; Karen Dunn; Saverio Tardito; Tessa L Holyoake; G Vignir Helgason; Eyal Gottlieb
Journal:  Nat Med       Date:  2017-09-18       Impact factor: 53.440
  9 in total
  1 in total

1.  Integrated lipidomics and proteomics reveal cardiolipin alterations, upregulation of HADHA and long chain fatty acids in pancreatic cancer stem cells.

Authors:  Claudia Di Carlo; Bebiana C Sousa; Marcello Manfredi; Jessica Brandi; Elisa Dalla Pozza; Emilio Marengo; Marta Palmieri; Ilaria Dando; Michael J O Wakelam; Andrea F Lopez-Clavijo; Daniela Cecconi
Journal:  Sci Rep       Date:  2021-06-24       Impact factor: 4.379
  1 in total

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