Mojtaba Falahati1, Farnoosh Attar2, Majid Sharifi3, Ali Akbar Saboury4, Abbas Salihi5, Falah Mohammad Aziz6, Irena Kostova7, Clemens Burda8, Peter Priecel9, Jose A Lopez-Sanchez9, Sophie Laurent10, Nasrin Hooshmand11, Mostafa A El-Sayed11. 1. Department of Nanotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Electronic address: Mojtaba.falahati@alumni.ut.ac.ir. 2. Department of Biology, Faculty of Food Industry & Agriculture, Standard Research Institute (SRI), Karaj, Iran. 3. Department of Nanotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Animal Science, Faculty of Agriculture, University of Tabriz, Tabriz, Iran. 4. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. 5. Department of Biology, College of Science, Salahaddin University-Erbil, Kurdistan Region, Iraq; Department of Medical Analysis, Faculty of Science, Tishk International University, Erbil, Iraq. 6. Department of Biology, College of Science, Salahaddin University-Erbil, Kurdistan Region, Iraq. 7. Department of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav St., Sofia 1000, Bulgaria. 8. Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States. 9. Stephenson Institute for Renewable Energy, Department of Chemistry, University of Liverpool, Crown Street, L69 7ZD Liverpool, United Kingdom. 10. General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau, 19, B-7000 Mons, Belgium; Center for Microscopy and Molecular Imaging (CMMI), Rue A. Bolland, 8 B-6041 Gosselies, Belgium. 11. Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, United States.
Abstract
BACKGROUND: Gold nanoparticles (AuNPs) with unique physicochemical properties have received a great deal of interest in the field of biological, chemical and biomedical implementations. Despite the widespread use of AuNPs in chemical and biological sensing, catalysis, imaging and diagnosis, and more recently in therapy, no comprehensive summary has been provided to explain how AuNPs could aid in developing improved sensing and catalysts systems as well as medical settings. SCOPE OF REVIEW: The chemistry of Au-based nanosystems was followed by reviewing different applications of Au nanomaterials in biological and chemical sensing, catalysis, imaging and diagnosis by a number of approaches, and finally synergistic combination therapy of different cancers. Afterwards, the clinical impacts of AuNPs, future application of AuNPs, and opportunities and challenges of AuNPs application were also discussed. MAJOR CONCLUSIONS: AuNPs show exclusive colloidal stability and are considered as ideal candidates for colorimetric detection, catalysis, imaging, and photothermal transducers, because their physicochemical properties can be tuned by adjusting their structural dimensions achieved by the different manufacturing methods. GENERAL SIGNIFICANCE: This review provides some details about using AuNPs in sensing and catalysis applications as well as promising theranostic nanoplatforms for cancer imaging and diagnosis, and sensitive, non-invasive, and synergistic methods for cancer treatment in an almost comprehensive manner.
BACKGROUND: Gold nanoparticles (AuNPs) with unique physicochemical properties have received a great deal of interest in the field of biological, chemical and biomedical implementations. Despite the widespread use of AuNPs in chemical and biological sensing, catalysis, imaging and diagnosis, and more recently in therapy, no comprehensive summary has been provided to explain how AuNPs could aid in developing improved sensing and catalysts systems as well as medical settings. SCOPE OF REVIEW: The chemistry of Au-based nanosystems was followed by reviewing different applications of Au nanomaterials in biological and chemical sensing, catalysis, imaging and diagnosis by a number of approaches, and finally synergistic combination therapy of different cancers. Afterwards, the clinical impacts of AuNPs, future application of AuNPs, and opportunities and challenges of AuNPs application were also discussed. MAJOR CONCLUSIONS: AuNPs show exclusive colloidal stability and are considered as ideal candidates for colorimetric detection, catalysis, imaging, and photothermal transducers, because their physicochemical properties can be tuned by adjusting their structural dimensions achieved by the different manufacturing methods. GENERAL SIGNIFICANCE: This review provides some details about using AuNPs in sensing and catalysis applications as well as promising theranostic nanoplatforms for cancer imaging and diagnosis, and sensitive, non-invasive, and synergistic methods for cancer treatment in an almost comprehensive manner.
Authors: Luis R Torres-Ferrer; José M López-Romero; Juan Mendez-Nonell; Maria J Rivas-Arreola; Marisa Moreno-Ríos; Erika O Ávila-Dávila; Evgeny Prokhorov; Yuriy Kovalenko; Diana G Zárate-Triviño; Javier R Revilla-Vazquez; Marco A Meraz-Rios; Gabriel Luna-Barcenas Journal: Polymers (Basel) Date: 2022-02-17 Impact factor: 4.329