Stefana Rafiroiu1, Habiba Hassouna2, Usman Ahmad3, Christine Koval2, Kenneth R McCurry3, Gösta B Pettersson3, Mudathir Ibrahim3, Douglas R Johnston3, Marie Budev4, Sudish C Murthy3, Andrew J Toth5, Eugene H Blackstone3, Michael Z Tong6. 1. Ohio University Heritage College of Osteopathic Medicine, Cleveland, Ohio. 2. Department of Infectious Disease, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio. 3. Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio. 4. Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio. 5. Department of Quantitative Health Sciences, Research Institute, Cleveland Clinic, Cleveland, Ohio. 6. Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address: tongz@ccf.org.
Abstract
BACKGROUND: Delayed chest closure is commonly used for cardiac surgery. However, insufficient data exist to guide its management in immunosuppressed lung transplantation patients, with unclear long-term consequences. METHODS: We performed 769 lung transplantations between January 2009 and January 2016. Of these, 47 (6%) required delayed chest closure because of coagulopathy, respiratory intolerance, and hemodynamic instability. On multivariable analysis, risk factors for delayed chest closure included double-lung transplantation and longer ischemic times. To account for differences between the 2 groups, we performed propensity matching, generating 46 well-matched pairs. RESULTS: Among matched patients with appropriate antimicrobial prophylaxis, we found no difference in 30-day prevalence of pneumonia, empyema, Clostridium difficile, bloodstream, and deep wound infections. There was also no difference in 6-month composite infections. However, delayed chest closure patients received more transfusions within 5 days of transplantation (median, 7 vs 3 units; P < .001), had more intubations > 5 days (80% vs 41%, P < .001), had more severe primary graft dysfunction (39% vs 17%, P = .044), had a longer hospital stay (median, 61 vs 25 days; P < .001), and had worse pulmonary function tests 6 years after transplant (P = .019). Fortunately, estimated survival at 6 months, 1 year, and 5 years between delayed and primary chest closure groups was similar (82%, 76%, and 39% vs 84%, 75%, and 50%, respectively; P = .23). CONCLUSIONS: Use of delayed chest closure does not yield more infections or worse long-term survival. However it may be associated with increased in-hospital morbidities and worse long-term pulmonary function.
BACKGROUND: Delayed chest closure is commonly used for cardiac surgery. However, insufficient data exist to guide its management in immunosuppressed lung transplantation patients, with unclear long-term consequences. METHODS: We performed 769 lung transplantations between January 2009 and January 2016. Of these, 47 (6%) required delayed chest closure because of coagulopathy, respiratory intolerance, and hemodynamic instability. On multivariable analysis, risk factors for delayed chest closure included double-lung transplantation and longer ischemic times. To account for differences between the 2 groups, we performed propensity matching, generating 46 well-matched pairs. RESULTS: Among matched patients with appropriate antimicrobial prophylaxis, we found no difference in 30-day prevalence of pneumonia, empyema, Clostridium difficile, bloodstream, and deep wound infections. There was also no difference in 6-month composite infections. However, delayed chest closure patients received more transfusions within 5 days of transplantation (median, 7 vs 3 units; P < .001), had more intubations > 5 days (80% vs 41%, P < .001), had more severe primary graft dysfunction (39% vs 17%, P = .044), had a longer hospital stay (median, 61 vs 25 days; P < .001), and had worse pulmonary function tests 6 years after transplant (P = .019). Fortunately, estimated survival at 6 months, 1 year, and 5 years between delayed and primary chest closure groups was similar (82%, 76%, and 39% vs 84%, 75%, and 50%, respectively; P = .23). CONCLUSIONS: Use of delayed chest closure does not yield more infections or worse long-term survival. However it may be associated with increased in-hospital morbidities and worse long-term pulmonary function.
Authors: Rodrigo Vazquez Guillamet; Maria C Vazquez Guillamet; Ashraf Rjob; Andrew Bierhals; Irene Bello; Alberto Jauregui Abularach; Laneshia Tague; Michael Wallendorf; Gary F Marklin; Chad Witt; Derek E Byers; Daniel Kreisel; Ruben Nava; Varun Puri; Ramsey Hachem; Elbert P Trulock Journal: J Thorac Dis Date: 2022-04 Impact factor: 3.005
Authors: Zhizhou Yang; Tsuyoshi Takahashi; William D Gerull; Christy Hamilton; Melanie P Subramanian; Jingxia Liu; Bryan F Meyers; Benjamin D Kozower; G Alexander Patterson; Ruben G Nava; Ramsey R Hachem; Chad A Witt; Patrick R Aguilar; Michael K Pasque; Derek E Byers; Hrishikesh S Kulkarni; Daniel Kreisel; Varun Puri Journal: Ann Thorac Surg Date: 2020-10-13 Impact factor: 5.102