Literature DB >> 31526756

Colon Cancer: Epithelial Notch Signaling Recruits Neutrophils to Drive Metastasis.

Jürgen Ruland1.   

Abstract

In this issue of Cancer Cell, Jackstadt et al. report that pathological Notch signaling in colorectal cancer (CRC) cells can initiate a neutrophil-dependent, TGF-β-mediated cascade that leads to metastatic disease. Inhibition of this pathway with clinically relevant compounds blocks metastatic spread in a developed murine model of CRC.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 31526756     DOI： 10.1016/j.ccell.2019.08.010

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

1.  HIST2H2BF Potentiates the Propagation of Cancer Stem Cells via Notch Signaling to Promote Malignancy and Liver Metastasis in Colorectal Carcinoma.

Authors:  Lei Qiu; Xiuwei Yang; Jingyu Wu; Changzhi Huang; Yongchang Miao; Zan Fu
Journal:  Front Oncol       Date:  2021-08-12       Impact factor: 6.244

Review 2.  Targeting TGF-β signal transduction for fibrosis and cancer therapy.

Authors:  Dandan Peng; Minyang Fu; Manni Wang; Yuquan Wei; Xiawei Wei
Journal:  Mol Cancer       Date:  2022-04-23       Impact factor: 41.444

3.  Immuno-genomic profiling of biopsy specimens predicts neoadjuvant chemotherapy response in esophageal squamous cell carcinoma.

Authors:  Shota Sasagawa; Hiroaki Kato; Koji Nagaoka; Changbo Sun; Motohiro Imano; Takao Sato; Todd A Johnson; Masashi Fujita; Kazuhiro Maejima; Yuki Okawa; Kazuhiro Kakimi; Takushi Yasuda; Hidewaki Nakagawa
Journal:  Cell Rep Med       Date:  2022-08-08

Review 4.  Notch-associated lncRNAs profiling circuiting epigenetic modification in colorectal cancer.

Authors:  Omnia Emam; Eman F Wasfey; Nadia M Hamdy
Journal:  Cancer Cell Int       Date:  2022-10-13       Impact factor: 6.429

5.  NICD3 regulates the expression of MUC5AC and MUC2 by recruiting SMARCA4 and is involved in the differentiation of mucinous colorectal adenocarcinoma.

Authors:  Xiaodong Yan; Yuan Cheng; Xia Zhang; Yi Hu; Haixia Huang; Jie Ren; Boye Wen; Yuhui Yang; Keyuan Xiao; Wenqing Hu; Wei Wang
Journal:  Mol Oncol       Date:  2022-08-11       Impact factor: 7.449

Review 6.  Tumor-Associated Neutrophils in Colorectal Cancer Development, Progression and Immunotherapy.

Authors:  Wei Zheng; Jingjing Wu; Yao Peng; Jing Sun; Pu Cheng; Qi Huang
Journal:  Cancers (Basel)       Date:  2022-09-29       Impact factor: 6.575

Review 7.  Functional Analysis of O-GlcNAcylation in Cancer Metastasis.

Authors:  Donglu Wu; Jingji Jin; Zhidong Qiu; Da Liu; Haoming Luo
Journal:  Front Oncol       Date:  2020-10-27       Impact factor: 6.244

Review 8.  Brief review on the roles of neutrophils in cancer development.

Authors:  Wang Long; Jingjing Chen; Chen Gao; Zhi Lin; Xubiao Xie; Helong Dai
Journal:  J Leukoc Biol       Date:  2020-09-24       Impact factor: 4.962

Review 9.  Notch signaling pathway: architecture, disease, and therapeutics.

Authors:  Binghan Zhou; Wanling Lin; Yaling Long; Yunkai Yang; Huan Zhang; Kongming Wu; Qian Chu
Journal:  Signal Transduct Target Ther       Date:  2022-03-24

10.  IRF1-mediated immune cell infiltration is associated with metastasis in colon adenocarcinoma.

Authors:  Yao-Jian Shao; Jun-Jie Ni; Shen-Yu Wei; Xiong-Peng Weng; Meng-Die Shen; Yi-Xin Jia; Li-Na Meng
Journal:  Medicine (Baltimore)       Date:  2020-09-11       Impact factor: 1.817
  10 in total

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