Lijun Tang1, Yingjie Fang2, Jianchun Yin3. 1. Institute of Physical Education, Shanghai Normal University, Shanghai 200234, China. 2. Spare-time Sports School, Yangpu District, Shanghai 200438, China. 3. Institute of Physical Education, Shanghai Normal University, Shanghai 200234, China. Electronic address: yjchun@shnu.edu.cn.
Abstract
OBJECTIVE: This work aimed to assess effects of different exercise intervention on Parkinson's disease (PD) treatment via a network meta-analysis. METHODS: Eligible literatures were retrieved from three databases (PubMed, EMBASE and Cochrane Library) up to March 5, 2019 and screened based on established selection criteria. Afterwards, relevant data was extracted and heterogeneity tests were conducted to select appropriate effect models according to chi-square test and I2 statistics. Publication bias of included studies was also performed. Finally, the pairwise and network meta-analyses were carried out to evaluate the efficacy of different exercise training on PD management. RESULTS: Overall, 19 studies encompassing 920 PD patients were identified to explore effects of interventions such as dance, Qigong, tango, resistance training (RT), Taichi and yoga on PD in terms of six indicators including six-minute walk, gait velocity, UPDRS III, PD questionnaire-39 (PDQ-39), timed up and go (TUG) and Berg balance test (BBT). The direct meta-analysis revealed that RT and dance altered the gait velocity and PDR-39 indicator of PD patients. And there was a statistical difference in RT and Tango regarding UPDRS III. Besides, significant differences were also detected among multiple comparisons based on TUG and BBT, containing RT vs control, Tai Chi vs control and Tango vs control for TUG, and dance vs control for BBT. Finally, results of network meta-analysis implied that tango was a good exercise for PD patients according to six different outcome measures. CONCLUSION: Tango was an optimal and effective option for improving functional mobility of PD patients.
OBJECTIVE: This work aimed to assess effects of different exercise intervention on Parkinson's disease (PD) treatment via a network meta-analysis. METHODS: Eligible literatures were retrieved from three databases (PubMed, EMBASE and Cochrane Library) up to March 5, 2019 and screened based on established selection criteria. Afterwards, relevant data was extracted and heterogeneity tests were conducted to select appropriate effect models according to chi-square test and I2 statistics. Publication bias of included studies was also performed. Finally, the pairwise and network meta-analyses were carried out to evaluate the efficacy of different exercise training on PD management. RESULTS: Overall, 19 studies encompassing 920 PDpatients were identified to explore effects of interventions such as dance, Qigong, tango, resistance training (RT), Taichi and yoga on PD in terms of six indicators including six-minute walk, gait velocity, UPDRS III, PD questionnaire-39 (PDQ-39), timed up and go (TUG) and Berg balance test (BBT). The direct meta-analysis revealed that RT and dance altered the gait velocity and PDR-39 indicator of PDpatients. And there was a statistical difference in RT and Tango regarding UPDRS III. Besides, significant differences were also detected among multiple comparisons based on TUG and BBT, containing RT vs control, Tai Chi vs control and Tango vs control for TUG, and dance vs control for BBT. Finally, results of network meta-analysis implied that tango was a good exercise for PDpatients according to six different outcome measures. CONCLUSION: Tango was an optimal and effective option for improving functional mobility of PDpatients.
Authors: Se Hee Jung; Naoya Hasegawa; Martina Mancini; Laurie A King; Patricia Carlson-Kuhta; Katrijn Smulders; Daniel S Peterson; Nancy Barlow; Graham Harker; Rosie Morris; Jodi Lapidus; John G Nutt; Fay B Horak Journal: NPJ Parkinsons Dis Date: 2020-11-02
Authors: Danielle Pessoa Lima; Samuel Brito de Almeida; Janine de Carvalho Bonfadini; Emmanuelle Silva Tavares Sobreira; Patrícia Gomes Damasceno; Antonio Brazil Viana Júnior; Madeleine Sales de Alencar; João Rafael Gomes de Luna; Pedro Gustavo Barros Rodrigues; Isabelle de Sousa Pereira; André Luis de Castro Gadelha; Liliane Maria de Oliveira; Érica Carneiro Barbosa Chaves; Vlademir Gomes Carneiro; Rayane Rodrigues Monteiro; Thatyara Almeida de Macedo Costa; Lucas Helal; Joseph Signorile; Lidiane Andréa Oliveira Lima; Manoel Alves Sobreira-Neto; Pedro Braga-Neto Journal: BMJ Open Date: 2020-10-12 Impact factor: 2.692