Literature DB >> 31526421

Moving Beyond 'Therapy' and 'Enhancement' in the Ethics of Gene Editing.

Bryan Cwik.   

Abstract

Since the advent of recombinant DNA technology, expectations (and trepidations) about the potential for altering genes and controlling our biology at the fundamental level have been sky high. These expectations have gone largely unfulfilled. But though the dream (or nightmare) of being able to control our biology is still far off, gene editing research has made enormous strides toward potential clinical use. This paper argues that when it comes to determining permissible uses of gene editing in one important medical context-germline intervention in reproductive medicine-issues about enhancement and eugenics are, for the foreseeable future, a red herring. Current translational goals for gene editing research involve a different kind of editing than would be required to achieve manipulation of complex traits such as intelligence, and there are more pressing (and unresolved) questions that need attention if clinical use of gene editing in reproductive medicine ever becomes a possibility.

Entities:  

Keywords:  enhancement; gene editing; genetics; reproductive medicine; research ethics; translational research

Year:  2019        PMID: 31526421      PMCID: PMC6751566          DOI: 10.1017/S0963180119000641

Source DB:  PubMed          Journal:  Camb Q Healthc Ethics        ISSN: 0963-1801            Impact factor:   1.284


  5 in total

Review 1.  Responsible Translational Pathways for Germline Gene Editing?

Authors:  Bryan Cwik
Journal:  Curr Stem Cell Rep       Date:  2020-08-21

Review 2.  Is Malaysia Ready for Human Gene Editing: A Regulatory, Biosafety and Biosecurity Perspective.

Authors:  V Kalidasan; Kumitaa Theva Das
Journal:  Front Bioeng Biotechnol       Date:  2021-03-11

3.  Revising, Correcting, and Transferring Genes.

Authors:  Bryan Cwik
Journal:  Am J Bioeth       Date:  2020-08       Impact factor: 11.229

4.  Attitudes of Indonesian Medical Doctors and Medical Students Toward Genome Editing.

Authors:  Safira Nur Izzah; Dimas Setyanto; Nurina Hasanatuludhhiyah; Danti Nur Indiastuti; Zamal Nasution; Annette d'Arqom
Journal:  J Multidiscip Healthc       Date:  2021-05-04

Review 5.  CRISPR-Cas and Its Wide-Ranging Applications: From Human Genome Editing to Environmental Implications, Technical Limitations, Hazards and Bioethical Issues.

Authors:  Roberto Piergentili; Alessandro Del Rio; Fabrizio Signore; Federica Umani Ronchi; Enrico Marinelli; Simona Zaami
Journal:  Cells       Date:  2021-04-21       Impact factor: 7.666

  5 in total

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