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Literature DB >> 31526214

Translational glycobiology: from bench to bedside.

John Axford¹, Azita Alavi¹, Rick Cummings², Gordan Lauc³, Ghislain Opdenakker⁴, Celso Reis⁵, Pauline Rudd⁶.

Abstract

The importance of sugars to protein function is real and is of significant clinical relevance. Technology advances enable large population studies to be carried out, shedding light on individual sugar variation and variations with time. Three-dimensional mass spectroscopy on solid pathological specimens is going to open up a whole new world of pathology visualisation. The door is now open to exploit carbohydrate recognition in new therapeutics by identifying novel biomarkers in cancer to aid diagnosis, and also providing therapeutic targets for treatment. Glycan age correlates with biological age. This means we can map the reversal of biological age with exercise and diet.

Entities: Chemical

Keywords: Allergy; immunology

Mesh：

Substances：

Year: 2019 PMID： 31526214 PMCID： PMC6794674 DOI： 10.1177/0141076819865863

Source DB: PubMed Journal: J R Soc Med ISSN： 0141-0768 Impact factor: 18.000

28 in total

Review 1. New developments in treating glycosphingolipid storage diseases.

Authors: Frances M Platt; Mylvaganam Jeyakumar; Ulrika Andersson; Raymond A Dwek; Terry D Butters
Journal: Adv Exp Med Biol Date: 2005 Impact factor: 2.622

Review 2. Epigenetic regulation of glycosylation is the quantum mechanics of biology.

Authors: Gordan Lauc; Aleksandar Vojta; Vlatka Zoldoš
Journal: Biochim Biophys Acta Date: 2013-08-31

3. Comparative effectiveness of interferons in relapsing-remitting multiple sclerosis: a meta-analysis of real-world studies.

Authors: Thomas R Einarson; Basil G Bereza; Márcio Machado
Journal: Curr Med Res Opin Date: 2017-01-11 Impact factor: 2.580

4. Microbiomic and Posttranslational Modifications as Preludes to Autoimmune Diseases.

Authors: Ghislain Opdenakker; Paul Proost; Jo Van Damme
Journal: Trends Mol Med Date: 2016-08-02 Impact factor: 11.951

Review 5. Cells regulate the activities of cytokines by glycosylation.

Authors: G Opdenakker; P M Rudd; M Wormald; R A Dwek; J Van Damme
Journal: FASEB J Date: 1995-03 Impact factor: 5.191

6. Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer.

Authors: Stefan Mereiter; Ana Magalhães; Barbara Adamczyk; Chunsheng Jin; Andreia Almeida; Lylia Drici; Maria Ibáñez-Vea; Catarina Gomes; José A Ferreira; Luis P Afonso; Lúcio L Santos; Martin R Larsen; Daniel Kolarich; Niclas G Karlsson; Celso A Reis
Journal: Biochim Biophys Acta Date: 2015-12-22

Review 7. Glycomics meets genomics, epigenomics and other high throughput omics for system biology studies.

Authors: Vlatka Zoldoš; Tomislav Horvat; Gordan Lauc
Journal: Curr Opin Chem Biol Date: 2013-01-01 Impact factor: 8.822

8. Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x.

Authors: Nuno T Marcos; Ana Magalhães; Bibiana Ferreira; Maria J Oliveira; Ana S Carvalho; Nuno Mendes; Tim Gilmartin; Steven R Head; Céu Figueiredo; Leonor David; Filipe Santos-Silva; Celso A Reis
Journal: J Clin Invest Date: 2008-06 Impact factor: 14.808

9. Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk.

Authors: Matthew R Kudelka; Benjamin H Hinrichs; Trevor Darby; Carlos S Moreno; Hikaru Nishio; Christopher E Cutler; Jianmei Wang; Huixia Wu; Junwei Zeng; Yingchun Wang; Tongzhong Ju; Sean R Stowell; Asma Nusrat; Rheinallt M Jones; Andrew S Neish; Richard D Cummings
Journal: Proc Natl Acad Sci U S A Date: 2016-12-07 Impact factor: 11.205

10. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

Authors: Gordan Lauc; Jennifer E Huffman; Maja Pučić; Lina Zgaga; Barbara Adamczyk; Ana Mužinić; Mislav Novokmet; Ozren Polašek; Olga Gornik; Jasminka Krištić; Toma Keser; Veronique Vitart; Blanca Scheijen; Hae-Won Uh; Mariam Molokhia; Alan Leslie Patrick; Paul McKeigue; Ivana Kolčić; Ivan Krešimir Lukić; Olivia Swann; Frank N van Leeuwen; L Renee Ruhaak; Jeanine J Houwing-Duistermaat; P Eline Slagboom; Marian Beekman; Anton J M de Craen; André M Deelder; Qiang Zeng; Wei Wang; Nicholas D Hastie; Ulf Gyllensten; James F Wilson; Manfred Wuhrer; Alan F Wright; Pauline M Rudd; Caroline Hayward; Yurii Aulchenko; Harry Campbell; Igor Rudan
Journal: PLoS Genet Date: 2013-01-31 Impact factor: 5.917

3 in total