Literature DB >> 31525641

Functions and mechanisms of miR-186 in human cancer.

Zhen Wang1, Huan-Huan Sha2, Hai-Jun Li3.   

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the post-transcriptional level. Mounting evidence suggests the involvement of miRNAs in carcinogenesis and the development of human cancer. Among the miRNAs, miR-186 has been extensively studied in various cancers. The expression of miR-186 in tissues varies depending on the type of cancer and miR-186 in tissues and body fluids may serve as a marker for the diagnosis and prognosis of cancers. Various biological processes in human cancer are affected by miR-186. Additionally, miR-186 itself is regulated by several factors. Thus, this evidence highlights the potential value of miR-186 in the diagnosis, prognosis and treatment of human cancer.
Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Entities:  

Keywords:  Cancer; Diagnosis; Prognosis; Regulation; Tumor biology; miR-186

Mesh：

Substances：

Year:  2019        PMID： 31525641     DOI： 10.1016/j.biopha.2019.109428

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN： 0753-3322            Impact factor:   6.529


  19 in total

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Authors:  Haofeng Liang; Lin Li; Shuang Zhu; Jianye Tan; Bingsheng Yang; Xiaoping Wang; Guofeng Wu; Chao Xie; Lutao Li; Zhengwei Liu; Yucong Li; Haoqiang Song; Guoli Chen; Lijun Lin
Journal:  Bioengineered       Date:  2022-05       Impact factor: 6.832

2.  CREB1 Suppresses Transcription of microRNA-186 to Promote Growth, Invasion and Epithelial-Mesenchymal Transition of Gastric Cancer Cells Through the KRT8/HIF-1α Axis.

Authors:  Xue Huang; Fujian Liu; Zhiyong Jiang; Hang Guan; Qiuhong Jia
Journal:  Cancer Manag Res       Date:  2020-09-25       Impact factor: 3.989

3.  Regulation of miR-186-YY1 axis by the p53 translational isoform ∆40p53: implications in cell proliferation.

Authors:  Aanchal Katoch; Sachin Kumar Tripathi; Apala Pal; Saumitra Das
Journal:  Cell Cycle       Date:  2021-02-25       Impact factor: 4.534

4.  miR‑27a‑3p regulates the inhibitory influence of endothelin 3 on the tumorigenesis of papillary thyroid cancer cells.

Authors:  Hongxin Chen; Binlin Cai; Kun Liu; Qingquan Hua
Journal:  Mol Med Rep       Date:  2021-02-04       Impact factor: 2.952

5.  Identification of prognostic miRNA biomarkers for esophageal cancer based on The Cancer Genome Atlas and Gene Expression Omnibus.

Authors:  Jinru Xue; Erna Jia; Na Ren; Hua Xin
Journal:  Medicine (Baltimore)       Date:  2021-02-19       Impact factor: 1.817

Review 6.  Roles and Mechanisms of the Long Noncoding RNAs in Cervical Cancer.

Authors:  Miguel Ángel Cáceres-Durán; Ândrea Ribeiro-Dos-Santos; Amanda Ferreira Vidal
Journal:  Int J Mol Sci       Date:  2020-12-21       Impact factor: 5.923

7.  Low miR-1273a expression predicts poor prognosis of colon cancer and facilitates tumor cell proliferation, migration, and invasion.

Authors:  Lei Sun; Xin Zhou; Qian Jiang; Yiping Zhuang; Dongzheng Li
Journal:  Braz J Med Biol Res       Date:  2021-01-08       Impact factor: 2.590

8.  MiR-186-3p attenuates tumorigenesis of cervical cancer by targeting IGF1.

Authors:  Xiurong Lu; Xiao Song; Xiaohui Hao; Xiaoyu Liu; Xianyu Zhang; Na Yuan; Huan Ma; Zhilin Zhang
Journal:  World J Surg Oncol       Date:  2021-07-12       Impact factor: 2.754

9.  Association of MALAT1 and PVT1 Variants, Expression Profiles and Target miRNA-101 and miRNA-186 with Colorectal Cancer: Correlation with Epithelial-Mesenchymal Transition.

Authors:  Abdullah F Radwan; Olfat G Shaker; Noha A El-Boghdady; Mahmoud A Senousy
Journal:  Int J Mol Sci       Date:  2021-06-07       Impact factor: 5.923

10.  miR-186 Represses Proliferation, Migration, Invasion, and EMT of Hepatocellular Carcinoma via Directly Targeting CDK6.

Authors:  Junfeng Lu; Zhongsong Zhao; Yanhong Ma
Journal:  Oncol Res       Date:  2020-07-22       Impact factor: 5.574
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