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Literature DB >> 315228

Inhibition of degradation of insulin by ophthalamic acid and by a bovine pancreatic proteinase inhibitor.

R E Offord, J Philippe, J G Davis, P A Halban, M Berger.

Abstract

We have previously observed that, on subcutaneous administration, a significant proportion of insulin is degraded at the site of injection. The present paper reports that the degradative activity of slices of rat adipose tissue can be inhibited in vitro by ophthalmic acid, a natural analogue of glutathione, and by bovine pancreatic proteinase inhibitor, whereas it is increased by the addition of reduced glutathione.

Entities: Chemical Disease Gene Species

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Year: 1979 PMID： 315228 PMCID： PMC1161257 DOI： 10.1042/bj1820249

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

11 in total

1. The mechanism of the glyoxalase I reaction, and the effect of ophthalmic acid as an inhibitor.

Authors: E E CLIFFE; S G WALEY
Journal: Biochem J Date: 1961-06 Impact factor: 3.857

2. Isolation of an insulin-degrading enzyme from beef liver.

Authors: H H TOMIZAWA; Y D HALSEY
Journal: J Biol Chem Date: 1959-02 Impact factor: 5.157

3. The degradation of semisynthetic tritiated insulin by perfused mouse livers.

Authors: P A Halban; C Karakash; J G Davies; R E Offord
Journal: Biochem J Date: 1976-11-15 Impact factor: 3.857

4. Degradation of insulin by isolated rat liver cells.

Authors: A Le Cam; P Freychet; P Lenoir
Journal: Diabetes Date: 1975-06 Impact factor: 9.461

5. Proteolytic degradation of insulin and glucagon.

Authors: W C Duckworth; M Heinemann; A E Kitabchi
Journal: Biochim Biophys Acta Date: 1975-02-19

6. Insulin degradation. VII. Sequential degradation of insulin by rat liver homogenates at physiologic concentrations of insulin and in the absence of exogenous glutathione.

Authors: P T Varandani
Journal: Biochim Biophys Acta Date: 1973-09-14

Review 7. Naturally occurring peptides.

Authors: S G Waley
Journal: Adv Protein Chem Date: 1966

Inhibition of degradation of insulin by ophthalamic acid and by a bovine pancreatic proteinase inhibitor.

1. The mechanism of the glyoxalase I reaction, and the effect of ophthalmic acid as an inhibitor.

2. Isolation of an insulin-degrading enzyme from beef liver.

3. The degradation of semisynthetic tritiated insulin by perfused mouse livers.

4. Degradation of insulin by isolated rat liver cells.

5. Proteolytic degradation of insulin and glucagon.

6. Insulin degradation. VII. Sequential degradation of insulin by rat liver homogenates at physiologic concentrations of insulin and in the absence of exogenous glutathione.

Review 7. Naturally occurring peptides.

8. Mobilization of subcutaneously injected tritiated insulin in rats: effects of muscular exercise.

9. Insulin degradation. XVI. Evidence for the sequential degradative pathway in isolated liver cells.

10. Insulinase, insulinase-inhibitors, and diabetes mellitus.

1. Production of Ophthalmic Acid Using Engineered Escherichia coli.

2. Evidence for insulin degradation by muscle and fat tissue in an insulin resistant diabetic patient.