Amir Goodarzi1, Nicholas Garza2, Mirna Lechpammer3, Reuben Anthony4, Marike Zwienenberg5. 1. Departments of Neurological Surgery, University of California, Davis, Sacramento, CA, USA. agoodarzi@ucdavis.edu. 2. School of Medicine, University of California, Davis, Sacramento, CA, USA. 3. Department of Pathology, University of California, Davis, Sacramento, CA, USA. 4. Department of Pediatric Hematology-Oncology, University of California, Davis, Sacramento, CA, USA. 5. Departments of Neurological Surgery, University of California, Davis, Sacramento, CA, USA.
Abstract
BACKGROUND: Bilateral thalamic astrocytomas in children are exceedingly rare. These highly malignant tumors seldom respond to conventional treatment strategies and carry a grim prognosis for patients. However, recent advances in molecular oncology have had a positive impact on prognostication and treatment strategies of these tumors. CASE-BASED REVIEW: We present a new case of WHO grade III bilateral thalamic astrocytoma in a child and review the pathophysiology, molecular oncogenesis, and relevant treatment strategies for this rare disease. CONCLUSIONS: High-grade thalamic astrocytomas affecting both thalami pose a challenge to pediatric neurosurgeons, neuro-oncologists, and neuropathologists given the lack of effective treatment strategies. Understanding recent revelations in the field of molecular oncology can assist clinicians in adequately formulating a treatment plan in this patient population.
BACKGROUND: Bilateral thalamic astrocytomas in children are exceedingly rare. These highly malignant tumors seldom respond to conventional treatment strategies and carry a grim prognosis for patients. However, recent advances in molecular oncology have had a positive impact on prognostication and treatment strategies of these tumors. CASE-BASED REVIEW: We present a new case of WHO grade III bilateral thalamic astrocytoma in a child and review the pathophysiology, molecular oncogenesis, and relevant treatment strategies for this rare disease. CONCLUSIONS: High-grade thalamic astrocytomas affecting both thalami pose a challenge to pediatric neurosurgeons, neuro-oncologists, and neuropathologists given the lack of effective treatment strategies. Understanding recent revelations in the field of molecular oncology can assist clinicians in adequately formulating a treatment plan in this patient population.
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