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Literature DB >> 31522075

Slaying a giant: Structures of calmodulin and protein kinase a bound to the cardiac ryanodine receptor.

Abstract

Ryanodine Receptors are Ca2+ release channels expressed in the Endoplasmic and Sarcoplasmic Reticulum membranes. Gong et al [1] reported cryo-EM structures of the cardiac RyR2 complexed to Calmodulin, which can downregulate channel opening. Haji-Ghassemi et al [2] report crystal structures of an RyR2 domain with PKA, a kinase promoting channel opening.

Entities: Chemical Gene

Keywords: Calcium release channel; Cryo-electron microscopy; Muscle excitation-contraction coupling; Ryanodine receptor; X-ray crystallography; cAMP-dependent protein kinease

Year: 2019 PMID： 31522075 DOI： 10.1016/j.ceca.2019.102079

Source DB: PubMed Journal: Cell Calcium ISSN： 0143-4160 Impact factor: 6.817

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Cited

3 in total

1. RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca²⁺ assays.

Authors: Robyn T Rebbeck; Daniel P Singh; Kevyn A Janicek; Donald M Bers; David D Thomas; Bradley S Launikonis; Razvan L Cornea
Journal: Sci Rep Date: 2020-02-04 Impact factor: 4.379

Review 2. Unbalance Between Sarcoplasmic Reticulum Ca^{2 +} Uptake and Release: A First Step Toward Ca^{2 +} Triggered Arrhythmias and Cardiac Damage.

Authors: Marilén Federico; Carlos A Valverde; Alicia Mattiazzi; Julieta Palomeque
Journal: Front Physiol Date: 2020-01-23 Impact factor: 4.566

3. Assessing the Role of Calmodulin's Linker Flexibility in Target Binding.

Authors: Bin Sun; Peter M Kekenes-Huskey
Journal: Int J Mol Sci Date: 2021-05-08 Impact factor: 5.923

3 in total

Slaying a giant: Structures of calmodulin and protein kinase a bound to the cardiac ryanodine receptor.

1. RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays.

Review 2. Unbalance Between Sarcoplasmic Reticulum Ca2 + Uptake and Release: A First Step Toward Ca2 + Triggered Arrhythmias and Cardiac Damage.

3. Assessing the Role of Calmodulin's Linker Flexibility in Target Binding.

1. RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca²⁺ assays.

Review 2. Unbalance Between Sarcoplasmic Reticulum Ca^{2 +} Uptake and Release: A First Step Toward Ca^{2 +} Triggered Arrhythmias and Cardiac Damage.