Attila Kollár1, Christian Rothermundt2, Frank Klenke3, Beata Bode4, Daniel Baumhoer5, Volker Arndt6, Anita Feller7. 1. Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, CH-3010 Bern, Switzerland. Electronic address: attila.kollar@insel.ch. 2. Department of Medical Oncology and Hematology, Cantonal Hospital St Gallen, Rorschacher Strasse 95, CH-9007 St Gallen, Switzerland. 3. Department of Orthopedic Surgery, Inselspital, Bern University Hospital, Freiburgstrasse, CH-3010 Bern, Switzerland. 4. University of Zurich and Institute of Pathology Enge, Hardturmstrasse 133, CH-8005 Zurich, Switzerland. 5. Bone Tumour Reference Centre at the Institute of Pathology, University Hospital and University of Basel, Schoenbeinstrasse 40, CH-4031 Basel, Switzerland. 6. Foundation National Institute for Cancer Epidemiology and Registration (NICER) c/o University of Zurich, Seilergraben 49, CH-8001 Zurich, Switzerland; Unit of Cancer Survivorship, Division of Clinical Epidemiology and Aging Research & Epidemiological Cancer Registry Baden-Württemberg, German Cancer Research Center (dkfz), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. 7. Foundation National Institute for Cancer Epidemiology and Registration (NICER) c/o University of Zurich, Seilergraben 49, CH-8001 Zurich, Switzerland.
Abstract
BACKGROUND: Research on soft-tissue sarcoma (STS) and bone sarcoma (BS) is increasingly in the focus of physicians and pharmaceutical companies. Expanding knowledge has improved the management of sarcoma and possibly survival. Here we provide the first population-based data on time trends of incidence, mortality, and survival of STS and BS diagnosed in Switzerland between 1996 and 2015. METHODS: We performed a retrospective registry study with data from the National Institute for Cancer Epidemiology and Registration (NICER) database in Switzerland between 1996 and 2015. RESULTS: We identified 5384 STS patients and 940 BS patients. The three most common STS subtypes were undifferentiated/unclassified sarcoma (22.3%), liposarcoma (20.6%) and leiomyosarcoma (20.6%). Chondrosarcoma, osteosarcoma and Ewing sarcoma represented 40.4%, 27.0% and 15.2% of the BS group, respectively. The age-standardized incidence and mortality rates in 2011-2015 were 4.43 and 1.42 per 100,000 person-years for STS, and 0.91 and 0.42 for BS. Age-standardized incidence of STS in males was significantly higher during 1996-2000 than during 2001-2015; however, mortality rates did not change significantly over time. Five-year relative survival (RS) for STS improved significantly from 56.4% (95%CI 52.9-59.7 for 1996-2001) to 61.6% (95%CI 58.6-64.4 for 2011-2015) (p = 0.025). No improvement in 5-year RS for BS could be observed (RS 1996-2000: 69.6%, 95%CI 61.2-76.6; RS 2011-2015: 73.1%, 95%CI 66.6-78.6; p = 0.479). CONCLUSION: Incidence rates of STS and BS have been stable since 2001. The longer RS in STS can be attributed to advances in sarcoma patient management.
BACKGROUND: Research on soft-tissue sarcoma (STS) and bone sarcoma (BS) is increasingly in the focus of physicians and pharmaceutical companies. Expanding knowledge has improved the management of sarcoma and possibly survival. Here we provide the first population-based data on time trends of incidence, mortality, and survival of STS and BS diagnosed in Switzerland between 1996 and 2015. METHODS: We performed a retrospective registry study with data from the National Institute for Cancer Epidemiology and Registration (NICER) database in Switzerland between 1996 and 2015. RESULTS: We identified 5384 STS patients and 940 BS patients. The three most common STS subtypes were undifferentiated/unclassified sarcoma (22.3%), liposarcoma (20.6%) and leiomyosarcoma (20.6%). Chondrosarcoma, osteosarcoma and Ewing sarcoma represented 40.4%, 27.0% and 15.2% of the BS group, respectively. The age-standardized incidence and mortality rates in 2011-2015 were 4.43 and 1.42 per 100,000 person-years for STS, and 0.91 and 0.42 for BS. Age-standardized incidence of STS in males was significantly higher during 1996-2000 than during 2001-2015; however, mortality rates did not change significantly over time. Five-year relative survival (RS) for STS improved significantly from 56.4% (95%CI 52.9-59.7 for 1996-2001) to 61.6% (95%CI 58.6-64.4 for 2011-2015) (p = 0.025). No improvement in 5-year RS for BS could be observed (RS 1996-2000: 69.6%, 95%CI 61.2-76.6; RS 2011-2015: 73.1%, 95%CI 66.6-78.6; p = 0.479). CONCLUSION: Incidence rates of STS and BS have been stable since 2001. The longer RS in STS can be attributed to advances in sarcomapatient management.
Authors: Jules Lansu; Winan J Van Houdt; Michael Schaapveld; Iris Walraven; Michiel A J Van de Sande; Vincent K Y Ho; Rick L Haas Journal: Sarcoma Date: 2020-09-22
Authors: Gabriela A Rojas; Aubrey K Hubbard; Brandon J Diessner; Karina B Ribeiro; Logan G Spector Journal: Int J Cancer Date: 2021-05-17 Impact factor: 7.316
Authors: Suzanne Bock; Douglas G Hoffmann; Yi Jiang; Hao Chen; Dora Il'yasova Journal: Int J Environ Res Public Health Date: 2020-04-15 Impact factor: 3.390