Laurent Maïmoun1, Patrick Lefebvre2, Safa Aouinti3, Marie-Christine Picot3, Denis Mariano-Goulart4, David Nocca5. 1. Service de Médecine Nucléaire, Hôpital Lapeyronie, CHU de Montpellier, Montpellier, France; PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France, Médicale, CHU de Montpellier, Montpellier, France. Electronic address: l-maimoun@chu-montpellier.fr. 2. Departement d'Endocrinologie, Diabetes, Nutrition, Hôpital Lapeyronie, CHU de Montpellier, Montpellier, France. 3. Unité de Recherche Clinique, Biostatistiques et Epidémiologie, Département de l'Information. 4. Service de Médecine Nucléaire, Hôpital Lapeyronie, CHU de Montpellier, Montpellier, France; PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France, Médicale, CHU de Montpellier, Montpellier, France. 5. Service de Chirurgie Digestive A, Hôpital Saint Eloi, CHU de Montpellier, Montpellier, France.
Abstract
BACKGROUND: Bariatric surgery induces weight loss but its acute and longer-term effects on body composition (BC) are largely unknown. OBJECTIVES: To determine the BC changes in obese French patients after sleeve gastrectomy (SG) at 1 and 12 months. SETTING: Obesity Reference Center, University Hospital of Montpellier, France. METHODS: Whole and localized BC (lean tissue mass [LTM] and fat mass [FM]) and abdominal adiposity, including total adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue, were determined by dual-energy X-ray absorptiometry in 30 obese patients (25 women, 83.3%) just before SG and 1 and 12 months later. RESULTS: The mean weight loss was -9.7 ± 2.6 kg at 1 month and -32.1 ± 10.3 kg at 12 months. This weight loss was due to an equivalent decrease in LTM and FM in the acute phase, while FM loss appeared to be the main cause in the chronic phase. For each component (LTM and FM), the loss was relatively homogeneous across sites. Compared with the presurgical values, android and gynoid tissue and total adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue changed significantly over the 12-month period. No basal clinical parameter was predictive of the variation in LTM, whereas age and the whole-body LTM/FM ratio were associated with the decrease in FM. CONCLUSION: This study demonstrates that SG induces a clear modification in BC, characterized by a decrease in LTM in the acute phase and sustained FM loss in the first year. These results suggest that the early phase should be targeted for strategies to reduce LTM loss, which is a longer-term weight-regain criterion. Further studies to investigate the potential advantages of visceral adipose tissue compared with whole-body FM for improving post-SG co-morbidities should be performed.
BACKGROUND: Bariatric surgery induces weight loss but its acute and longer-term effects on body composition (BC) are largely unknown. OBJECTIVES: To determine the BC changes in obese French patients after sleeve gastrectomy (SG) at 1 and 12 months. SETTING: Obesity Reference Center, University Hospital of Montpellier, France. METHODS: Whole and localized BC (lean tissue mass [LTM] and fat mass [FM]) and abdominal adiposity, including total adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue, were determined by dual-energy X-ray absorptiometry in 30 obesepatients (25 women, 83.3%) just before SG and 1 and 12 months later. RESULTS: The mean weight loss was -9.7 ± 2.6 kg at 1 month and -32.1 ± 10.3 kg at 12 months. This weight loss was due to an equivalent decrease in LTM and FM in the acute phase, while FM loss appeared to be the main cause in the chronic phase. For each component (LTM and FM), the loss was relatively homogeneous across sites. Compared with the presurgical values, android and gynoid tissue and total adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue changed significantly over the 12-month period. No basal clinical parameter was predictive of the variation in LTM, whereas age and the whole-body LTM/FM ratio were associated with the decrease in FM. CONCLUSION: This study demonstrates that SG induces a clear modification in BC, characterized by a decrease in LTM in the acute phase and sustained FM loss in the first year. These results suggest that the early phase should be targeted for strategies to reduce LTM loss, which is a longer-term weight-regain criterion. Further studies to investigate the potential advantages of visceral adipose tissue compared with whole-body FM for improving post-SG co-morbidities should be performed.
Authors: Jonathan Sivakumar; Qianyu Chen; Tom R Sutherland; Matthew Read; Salena Ward; Lynn Chong; Michael W Hii Journal: Obes Surg Date: 2022-06-01 Impact factor: 3.479
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Authors: Nicole M Gilbertson; Natalie Z M Eichner; Julian M Gaitán; Mahnoor Khurshid; Elizabeth A Rexrode; Sibylle Kranz; Peter T Hallowell; Steven K Malin Journal: Physiol Rep Date: 2021-11
Authors: Karynne Grutter Lopes; Maria das Graças Coelho de Souza; Michelle da Costa Tavares Bezerra; Lucas Miranda Bessa; Paulo Farinatti; Eliete Bouskela; Miguel Madeira; Luiz Guilherme Kraemer-Aguiar Journal: Trials Date: 2022-09-02 Impact factor: 2.728