Mohammad Beba1, Kurosh Djafarian1, Sakineh Shab-Bidar2. 1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. 2. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: s_shabbidar@tums.ac.ir.
Abstract
OBJECTIVES: Clinical evidence suggests the beneficial effects of Berberine (BER) on inflammatory markers. However, these results are controversial. The aim of this systematic review was to assess the effects of BER on C-reactive protein (CRP) using clinical trials in adults. DESIGN: Systematic review and meta-analysis. MAIN OUTCOME MEASURES: We searched randomized controlled trials in PubMed and Scopus up to November 2018. The mean differences (MD) and confidence interval (CI) of CRP (mg/L) concentrations were pooled with a random- or a fixed-effects model depending on the results of heterogeneity tests. RESULTS: Of 1242 studies identified, 5 were included in the meta-analysis. Pooled analysis showed that serum levels of CRP were decreased after BER supplementation (MD:-0.64 mg/L, 95% CI(-0.67 to -0.61) P < 0.001)) without any significant heterogeneity (I2 = 0.0% and P = 0.984). CONCLUSION: This meta-analysis showed BER supplementation may ameliorate the state of chronic inflammation. Patients with cardiovascular disease and diabetes are two important groups which may benefit from BER supplementation. Further well-designed investigations with larger samples are needed to ascertain the long-term effects of BER on chronic inflammation.
OBJECTIVES: Clinical evidence suggests the beneficial effects of Berberine (BER) on inflammatory markers. However, these results are controversial. The aim of this systematic review was to assess the effects of BER on C-reactive protein (CRP) using clinical trials in adults. DESIGN: Systematic review and meta-analysis. MAIN OUTCOME MEASURES: We searched randomized controlled trials in PubMed and Scopus up to November 2018. The mean differences (MD) and confidence interval (CI) of CRP (mg/L) concentrations were pooled with a random- or a fixed-effects model depending on the results of heterogeneity tests. RESULTS: Of 1242 studies identified, 5 were included in the meta-analysis. Pooled analysis showed that serum levels of CRP were decreased after BER supplementation (MD:-0.64 mg/L, 95% CI(-0.67 to -0.61) P < 0.001)) without any significant heterogeneity (I2 = 0.0% and P = 0.984). CONCLUSION: This meta-analysis showed BER supplementation may ameliorate the state of chronic inflammation. Patients with cardiovascular disease and diabetes are two important groups which may benefit from BER supplementation. Further well-designed investigations with larger samples are needed to ascertain the long-term effects of BER on chronic inflammation.
Authors: Laine de Carvalho Guerra Pessoa Mamede; Rafaela Lira Formiga Cavalcanti de Lima; Alexandre Sérgio Silva; João Carlos Lima Rodrigues Pita; Nadjeanny Ingrid Galdino Gomes; Elisama Araújo de Sena; Rhayra Priscila Moraes Nobrega; João Otávio Scarano Alcântara; Julie Hanna Fontes de Souza; Glêbia Alexa Cardoso; José Luiz de Brito Alves; Maria da Conceição Rodrigues Gonçalves Journal: Diabetes Metab Syndr Obes Date: 2021-02-04 Impact factor: 3.168