Nitish Kamble1, Ravi Yadav1, Abhishek Lenka2, Keshav Kumar3, B C Nagaraju1, Pramod Kumar Pal4. 1. Departments of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India. 2. Departments of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India; Departments of Clinical Neurosciences, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India. 3. Departments of Clinical Psychology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India. 4. Departments of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India. Electronic address: pal.pramod@rediffmail.com.
Abstract
OBJECTIVES: The present study was undertaken to evaluate the cognitive profile of Parkinson's disease (PD) patients with REM sleep behavior disorder (RBD) and to correlate with the clinical stage and polysomnographic variables. METHODS: The study included 25 PD patients who had RBD and 25 PD patients who based on two questionnaires were determined as not having RBD. These patients underwent overnight polysomnography (PSG) and neuropsychological assessment using a defined battery of tests. RESULTS: The mean age of the patients with clinically probable RBD (RBD+) was 60.4 ± 8.2 years and PD patients without RBD (RBD-) was 57.3 ± 6.6 years (p = 0.14). The mean age at onset of the disease was 53.7 ± 9.4 years for RBD+ and 49.8 ± 7.8 years for RBD-patients (p = 0.12). The mean Unified Parkinson Disease Rating Scale (UPDRS) part III OFF score was 27.4 ± 11.1 for RBD+ and 32.7 ± 8.2 for RBD- (p = 0.06). The total sleep time of the patients was 4.3 ± 1.7 h with sleep efficiency of 53.8 ± 21.0%. Patients with RBD+ were found to have significant impairment in many neuropsychological tests compared to RBD-. CONCLUSIONS: RBD + patients had significant impairment in MMSE, category fluency test (FAS test), frontal assessment battery, attention (digit span backwards, Corsi span), verbal memory (story recall) and Rey's auditory verbal learning test. These patients also had poor sleep quality.
OBJECTIVES: The present study was undertaken to evaluate the cognitive profile of Parkinson's disease (PD) patients with REM sleep behavior disorder (RBD) and to correlate with the clinical stage and polysomnographic variables. METHODS: The study included 25 PDpatients who had RBD and 25 PDpatients who based on two questionnaires were determined as not having RBD. These patients underwent overnight polysomnography (PSG) and neuropsychological assessment using a defined battery of tests. RESULTS: The mean age of the patients with clinically probable RBD (RBD+) was 60.4 ± 8.2 years and PDpatients without RBD (RBD-) was 57.3 ± 6.6 years (p = 0.14). The mean age at onset of the disease was 53.7 ± 9.4 years for RBD+ and 49.8 ± 7.8 years for RBD-patients (p = 0.12). The mean Unified Parkinson Disease Rating Scale (UPDRS) part III OFF score was 27.4 ± 11.1 for RBD+ and 32.7 ± 8.2 for RBD- (p = 0.06). The total sleep time of the patients was 4.3 ± 1.7 h with sleep efficiency of 53.8 ± 21.0%. Patients with RBD+ were found to have significant impairment in many neuropsychological tests compared to RBD-. CONCLUSIONS: RBD + patients had significant impairment in MMSE, category fluency test (FAS test), frontal assessment battery, attention (digit span backwards, Corsi span), verbal memory (story recall) and Rey's auditory verbal learning test. These patients also had poor sleep quality.
Authors: Jonathan Trout; Taylor Christiansen; M Brooks Bulkley; Jared J Tanner; Christopher N Sozda; Dawn Bowers; Daniel B Kay Journal: Brain Sci Date: 2019-12-21