Jan Pfeiffenberger1, Daniel Hornuss2, Philip Houben3, Cyrill Wehling4, Rebecca Von Haken5, Markus Mieth6, Arianeb Mehrabi7, Karl-Heinz Weiss8, Kilian Friedrich9. 1. Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg. . jan.pfeiffenberger@med.uni-heidelberg.de. 2. Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg. Daniel.hornuss@med.uni-heidelberg.de. 3. Department of General, Visceral and Tansplant Surgery, University Hospital of Heidelberg. philip.houben@med.uni-heidelberg.de. 4. Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg. Cyrill.Wehling@med.uni-heidelberg.de. 5. Department of Anaesthesiology, University Hospital of Heidelberg. Rebecca.vonhaken@med.uni-heidelberg.de. 6. Department of General, Visceral and Tansplant Surgery, University Hospital of Heidelberg. markus.mieth@med.uni-heidelberg.de. 7. Department of General, Visceral and Tansplant Surgery, University Hospital of Heidelberg. arianeb.mehrabi@med.uni-heidelberg.de. 8. Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg. karl-heinz.weiss@med.uni-heidelberg.de. 9. Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg. kilianfriedrich@gmx.de.
Abstract
BACKGROUND AND AIMS: Transient elastography (TE) has routinely been implemented in the diagnosis and assessment of chronic liver disease. Little data are available in the post liver transplant (LTx) setting. METHODS: Three months after LTx, we performed TE in 137 liver transplant recipients and investigated its predictive value upon further clinical outcome. The mean follow-up time for clinical outcome was 24 months. RESULTS: Mean TE value was 10.6 kPa (± 6.3 kPa; range 2.8 - 29.9 kPa). There was a significant correlation between TE and aspartate aminotransferase (AST) (p=0.004), gamma-glutamyl transferase (GGT) (p=0.031) and bilirubin (p<0.001) serum levels. In Cox univariate analysis, TE served as a predictor of actuarial survival free of liver transplantation (OR=1.111, 95%CI: 1.051-1.174; p<0.001). In multivariate analysis, TE remained an independent risk factor associated with reduced actuarial survival free of liver transplantation (OR=1.080, 95%CI: 1.001-1.166; p=0.047), along with thrombocytes (OR=0.992, 95%CI: 0.986-0.999; p=0.020) and metabolic co-disease (OR = 0.250, 95%CI: 0.070-0.895; p=0.033). CONCLUSION: Transient elastography measurement at three months after LTx seems a robust predictor of survival in liver transplant recipients.
BACKGROUND AND AIMS: Transient elastography (TE) has routinely been implemented in the diagnosis and assessment of chronic liver disease. Little data are available in the post liver transplant (LTx) setting. METHODS: Three months after LTx, we performed TE in 137 liver transplant recipients and investigated its predictive value upon further clinical outcome. The mean follow-up time for clinical outcome was 24 months. RESULTS: Mean TE value was 10.6 kPa (± 6.3 kPa; range 2.8 - 29.9 kPa). There was a significant correlation between TE and aspartate aminotransferase (AST) (p=0.004), gamma-glutamyl transferase (GGT) (p=0.031) and bilirubin (p<0.001) serum levels. In Cox univariate analysis, TE served as a predictor of actuarial survival free of liver transplantation (OR=1.111, 95%CI: 1.051-1.174; p<0.001). In multivariate analysis, TE remained an independent risk factor associated with reduced actuarial survival free of liver transplantation (OR=1.080, 95%CI: 1.001-1.166; p=0.047), along with thrombocytes (OR=0.992, 95%CI: 0.986-0.999; p=0.020) and metabolic co-disease (OR = 0.250, 95%CI: 0.070-0.895; p=0.033). CONCLUSION: Transient elastography measurement at three months after LTx seems a robust predictor of survival in liver transplant recipients.
Authors: Kerstin Herzer; Martina Sterneck; Martin-Walter Welker; Silvio Nadalin; Gabriele Kirchner; Felix Braun; Christina Malessa; Adam Herber; Johann Pratschke; Karl Heinz Weiss; Elmar Jaeckel; Frank Tacke Journal: J Clin Med Date: 2020-11-05 Impact factor: 4.241