Literature DB >> 31516113

A Clinicoepidemiological Study of Pediatric Cutaneous Leishmaniasis in Sinjar Province, Iraq.

Nawfal R Hussein1.   

Abstract

Cutaneous leishmaniasis (CL) is a major health problem worldwide. Although CL is a common disease among children, treatment regimens for the pediatric age group are based on extrapolation of efficacy data in adults. The present study aimed to evaluate the treatment outcome of CL in preschool-age children and the factors influencing the outcome. Two hundred ninety-four children were diagnosed with CL between December 2018 and March 2019 in Sinjar Province, Iraq. All patients were treated with intralesional injections of sodium stibogluconate and followed up for 3 months after the completion of treatment. The treatment success rate was 99% (291/294). A statistically significant association was found between the number of doses per lesion and the number of lesions (P = 0.002; CI = 0.066-0.2875). No association was found between the number of lesions, age, gender, or the presence of livestock and the treatment outcome. In conclusion, treatment success rate was high with the use of intralesional injection of sodium stibogluconate. A significant association was found between the number of lesions and the number of doses. Further studies are required to assess the treatment outcome indicators, including the genotype of leishmania.

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Year:  2019        PMID: 31516113      PMCID: PMC6838578          DOI: 10.4269/ajtmh.19-0508

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN: 0002-9637            Impact factor:   2.345


  22 in total

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2.  Combating tropical infectious diseases: report of the Disease Control Priorities in Developing Countries Project.

Authors:  Peter J Hotez; Jan H F Remme; Paulo Buss; George Alleyne; Carlos Morel; Joel G Breman
Journal:  Clin Infect Dis       Date:  2004-02-26       Impact factor: 9.079

3.  Treatment failure in children in a randomized clinical trial with 10 and 20 days of meglumine antimonate for cutaneous leishmaniasis due to Leishmania viannia species.

Authors:  R Palacios; L E Osorio; L F Grajalew; M T Ochoa
Journal:  Am J Trop Med Hyg       Date:  2001 Mar-Apr       Impact factor: 2.345

4.  Comparison of intralesional meglumine antimoniate, cryotherapy and their combination in the treatment of cutaneous leishmaniasis.

Authors:  Rahmatolah Salmanpour; Mohammad Reza Razmavar; Noshin Abtahi
Journal:  Int J Dermatol       Date:  2006-09       Impact factor: 2.736

5.  Leishmaniasis and poverty.

Authors:  Jorge Alvar; Sergio Yactayo; Caryn Bern
Journal:  Trends Parasitol       Date:  2006-10-04

6.  Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children.

Authors:  Luisa Consuelo Rubiano; María Consuelo Miranda; Sandra Muvdi Arenas; Luz Mery Montero; Isabel Rodríguez-Barraquer; Daniel Garcerant; Martín Prager; Lyda Osorio; Maria Ximena Rojas; Mauricio Pérez; Ruben Santiago Nicholls; Nancy Gore Saravia
Journal:  J Infect Dis       Date:  2012-01-11       Impact factor: 5.226

7.  Systemic meglumine antimoniate in acute cutaneous leishmaniasis: children versus adults.

Authors:  Pouran Layegh; Sara Rahsepar; Amir Ali Rahsepar
Journal:  Am J Trop Med Hyg       Date:  2011-04       Impact factor: 2.345

8.  Pediatric Cutaneous Leishmaniasis in an Endemic Region in Turkey: A Retrospective Analysis of 8786 Cases during 1998-2014.

Authors:  Mustafa Aksoy; Nebiye Doni; Hatice Uce Ozkul; Yavuz Yesilova; Nurittin Ardic; Abdullah Yesilova; Jennifer Ahn-Jarvis; Steve Oghumu; Cesar Terrazas; Abhay R Satoskar
Journal:  PLoS Negl Trop Dis       Date:  2016-07-14

9.  Risk factors for therapeutic failure to meglumine antimoniate and miltefosine in adults and children with cutaneous leishmaniasis in Colombia: A cohort study.

Authors:  Maria Del Mar Castro; Alexandra Cossio; Carlos Velasco; Lyda Osorio
Journal:  PLoS Negl Trop Dis       Date:  2017-04-05

10.  Interventions to treat cutaneous leishmaniasis in children: A systematic review.

Authors:  Andrés Uribe-Restrepo; Alexandra Cossio; Mayur M Desai; Diana Dávalos; María Del Mar Castro
Journal:  PLoS Negl Trop Dis       Date:  2018-12-14
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