Literature DB >> 31516038

Circulating Cell Free Nuclear DNA, Mitochondrial DNA and Global DNA Methylation: Potential Noninvasive Biomarkers for Breast Cancer Diagnosis.

Heba A Pasha1, Noha A Rezk1, Mohamed A Riad2.   

Abstract

Eighty seven women with benign breast lesion, 120 patients with breast cancer (BC) and one hundred controls were included in the study. Quantification of mtDNA and nDNA was done by qPCR. Global DNA methylation was measured using ELISA. Circulating cell-free nDNA and mtDNA were significantly elevated in BC and benign breast lesions patients. Global methylation was significantly low in BC patients. Combining the studied parameters in one panel, nDNA/mtDNA/hypomethylation, improved their sensitivity in detecting BC to reach 92.5%. Circulating cell-free nDNA, mtDNA and global DNA hypomethylation can be used as diagnostic and prognostic markers for BC.

Entities:  

Keywords:  Breast cancer; hypomethylation; methylation; mtDNA; nDNA

Mesh：

Substances：

Year:  2019        PMID： 31516038     DOI： 10.1080/07357907.2019.1663864

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  5 in total

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Journal:  Front Oncol       Date:  2021-02-04       Impact factor: 6.244

4.  Plasma cell-free DNA methylation combined with tumor mutation detection in prognostic prediction of patients with non-small cell lung cancer (NSCLC).

Authors:  Dan Guo; Liang Yang; Jianwei Yang; Ke Shi
Journal:  Medicine (Baltimore)       Date:  2020-06-26       Impact factor: 1.817

Review 5.  Clinical Relevance of Liquid Biopsy in Melanoma and Merkel Cell Carcinoma.

Authors:  Magali Boyer; Laure Cayrefourcq; Olivier Dereure; Laurent Meunier; Ondine Becquart; Catherine Alix-Panabières
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  5 in total

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