Literature DB >> 31516001

Identification of Adenosine-to-Inosine RNA Editing with Acrylonitrile Reagents.

Ying Li1,2, Matthias Göhl3, Ke Ke1, Christopher D Vanderwal1,3, Robert C Spitale1,3.   

Abstract

New chemical probes have been designed to facilitate the identification of adenosine-to-inosine (A-to-I) edited RNAs. These reagents combine a conjugate acceptor for selective inosine covalent modification with functional groups for bioorthogonal biotinylation. The resulting biotinylated RNA was enriched and verified with RT-qPCR. This powerful chemical approach provides new opportunities to identify and quantify A-to-I editing sites.

Entities:  

Year:  2019        PMID： 31516001      PMCID： PMC7308179          DOI： 10.1021/acs.orglett.9b02929

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  19 in total

Review 1.  Double-stranded RNA as a template for gene silencing.

Authors:  B L Bass
Journal:  Cell       Date:  2000-04-28       Impact factor: 41.582

2.  RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.

Authors:  B Sommer; M Köhler; R Sprengel; P H Seeburg
Journal:  Cell       Date:  1991-10-04       Impact factor: 41.582

3.  Inosine exists in mRNA at tissue-specific levels and is most abundant in brain mRNA.

Authors:  M S Paul; B L Bass
Journal:  EMBO J       Date:  1998-02-16       Impact factor: 11.598

4.  Transcriptome-wide identification of adenosine-to-inosine editing using the ICE-seq method.

Authors:  Tsutomu Suzuki; Hiroki Ueda; Shunpei Okada; Masayuki Sakurai
Journal:  Nat Protoc       Date:  2015-04-09       Impact factor: 13.491

5.  Widespread inosine-containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation.

Authors:  Jing-Hua Yang; Xiaoxing Luo; Yongzhan Nie; Yingjun Su; Qingchuan Zhao; Koroush Kabir; Dexin Zhang; Reuven Rabinovici
Journal:  Immunology       Date:  2003-05       Impact factor: 7.397

6.  Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome.

Authors:  Masayuki Sakurai; Takanori Yano; Hitomi Kawabata; Hiroki Ueda; Tsutomu Suzuki
Journal:  Nat Chem Biol       Date:  2010-09-12       Impact factor: 15.040

7.  Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma.

Authors:  Eimile Oakes; Ashley Anderson; Aaron Cohen-Gadol; Heather A Hundley
Journal:  J Biol Chem       Date:  2017-02-06       Impact factor: 5.157

8.  A Fluorescent Adenosine Analogue as a Substrate for an A-to-I RNA Editing Enzyme.

Authors:  Rena A Mizrahi; Dongwon Shin; Renatus W Sinkeldam; Kelly J Phelps; Andrea Fin; Dean J Tantillo; Yitzhak Tor; Peter A Beal
Journal:  Angew Chem Int Ed Engl       Date:  2015-06-10       Impact factor: 15.336

9.  Chemical Labeling and Affinity Capture of Inosine-Containing RNAs Using Acrylamidofluorescein.

Authors:  Steve D Knutson; Tewoderos M Ayele; Jennifer M Heemstra
Journal:  Bioconjug Chem       Date:  2018-08-27       Impact factor: 4.774

10.  Selective Recognition of RNA Substrates by ADAR Deaminase Domains.

Authors:  Yuru Wang; SeHee Park; Peter A Beal
Journal:  Biochemistry       Date:  2018-02-21       Impact factor: 3.162
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  5 in total

1.  Chemical Profiling of A-to-I RNA Editing Using a Click-Compatible Phenylacrylamide.

Authors:  Steve D Knutson; Megan M Korn; Ryan P Johnson; Leanna R Monteleone; Deanna M Dailey; Colin S Swenson; Peter A Beal; Jennifer M Heemstra
Journal:  Chemistry       Date:  2020-06-17       Impact factor: 5.236

2.  Selective Enrichment of A-to-I Edited Transcripts from Cellular RNA Using Endonuclease V.

Authors:  Steve D Knutson; Robert A Arthur; H Richard Johnston; Jennifer M Heemstra
Journal:  J Am Chem Soc       Date:  2020-03-05       Impact factor: 15.419

3.  Harnessing Nature's Molecular Recognition Capabilities to Map and Study RNA Modifications.

Authors:  Ansley S Felix; Alexandria L Quillin; Shikufa Mousavi; Jennifer M Heemstra
Journal:  Acc Chem Res       Date:  2022-07-28       Impact factor: 24.466

4.  EndoVIPER-seq for Improved Detection of A-to-I Editing Sites in Cellular RNA.

Authors:  Steve D Knutson; Jennifer M Heemstra
Journal:  Curr Protoc Chem Biol       Date:  2020-06

Review 5.  A-to-I RNA Editing in Cancer: From Evaluating the Editing Level to Exploring the Editing Effects.

Authors:  Heming Wang; Sinuo Chen; Jiayi Wei; Guangqi Song; Yicheng Zhao
Journal:  Front Oncol       Date:  2021-02-11       Impact factor: 6.244
  5 in total

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