Jian Zhou1,2,3,4, Yaping Wei5, Yuan Lan6, Jingjing Zuo6, Xiangqing Hou5, Weikai Hou7,8,9. 1. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, People's Republic of China. 2. Institute of Endocrinology and Metabolism, Shandong University, Jinan, 250012, Shandong, People's Republic of China. 3. Key Laboratory of Endocrinology and Metabolism, Shandong Province in Medicine and Health, No. 107 West Culture Road, Jinan, 250012, Shandong, People's Republic of China. 4. Department of Geriatrics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, People's Republic of China. 5. Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, People's Republic of China. 6. School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China. 7. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, People's Republic of China. wkhou_qilu@126.com. 8. Institute of Endocrinology and Metabolism, Shandong University, Jinan, 250012, Shandong, People's Republic of China. wkhou_qilu@126.com. 9. Key Laboratory of Endocrinology and Metabolism, Shandong Province in Medicine and Health, No. 107 West Culture Road, Jinan, 250012, Shandong, People's Republic of China. wkhou_qilu@126.com.
Abstract
BACKGROUND AND OBJECTIVES: Accumulating evidences suggest that chronic systemic inflammation (CSI) is independently associated with large number of major non-communicable chronic diseases (NCDs) ranging from metabolic disorders to cancers, and neutrophil-to-lymphocyte ratio (NLR) has been accepted as a novel, convenient marker for CSI response. Testosterone deficiency in men is linked to high risk of NCDs. This cross-sectional study aimed to investigate the individual and joint association of bioavailable testosterone (BIOT) and aging with NLR. METHODS: A total of 132 male adults were enrolled during Jan. 2011 and Oct. 2017 in the first affiliated hospital of University of Science and Technology of China. Local weighted regression (LOESS) and multivariable generalized linear regression models were utilized to comprehensively examine the individual and joint association between BIOT and age with NLR. RESULTS: Obvious linear relationships between NLR and BIOT or age were observed with the LOESS models. NLR was negatively correlated to BIOT after adjusting for some potential confounding factors (P = 0.034). As compared to the lowest quartile of BIOT, the adjusted decrease of NLR for the 2nd, 3rd and 4th quartiles were 0.40, 0.64 and 0.72, respectively. Meanwhile, NLR was observed to be independently correlated to elevated age (P = 0.043). Furthermore, as compared to the counterparts, men over 70 years combined with plasma BIOT less than 4.7 nmol/L had the highest NLR level, which suggested that low BIOT and aging jointly correlated to the level of NLR (P = 0.005). CONCLUSION: BIOT deficiency and aging were individually and jointly correlated to CSI. Men over 70 years combined with BIOT < 4.7 nmol/L were more like to have higher grade of CSI than others.
BACKGROUND AND OBJECTIVES: Accumulating evidences suggest that chronic systemic inflammation (CSI) is independently associated with large number of major non-communicable chronic diseases (NCDs) ranging from metabolic disorders to cancers, and neutrophil-to-lymphocyte ratio (NLR) has been accepted as a novel, convenient marker for CSI response. Testosterone deficiency in men is linked to high risk of NCDs. This cross-sectional study aimed to investigate the individual and joint association of bioavailable testosterone (BIOT) and aging with NLR. METHODS: A total of 132 male adults were enrolled during Jan. 2011 and Oct. 2017 in the first affiliated hospital of University of Science and Technology of China. Local weighted regression (LOESS) and multivariable generalized linear regression models were utilized to comprehensively examine the individual and joint association between BIOT and age with NLR. RESULTS: Obvious linear relationships between NLR and BIOT or age were observed with the LOESS models. NLR was negatively correlated to BIOT after adjusting for some potential confounding factors (P = 0.034). As compared to the lowest quartile of BIOT, the adjusted decrease of NLR for the 2nd, 3rd and 4th quartiles were 0.40, 0.64 and 0.72, respectively. Meanwhile, NLR was observed to be independently correlated to elevated age (P = 0.043). Furthermore, as compared to the counterparts, men over 70 years combined with plasma BIOT less than 4.7 nmol/L had the highest NLR level, which suggested that low BIOT and aging jointly correlated to the level of NLR (P = 0.005). CONCLUSION:BIOTdeficiency and aging were individually and jointly correlated to CSI. Men over 70 years combined with BIOT < 4.7 nmol/L were more like to have higher grade of CSI than others.
Entities:
Keywords:
Aging; Bioavailable testosterone; Chronic systematic inflammation; Neutrophil-to-lymphocyte ratio
Authors: Elena Rodríguez-Rodríguez; Ana M López-Sobaler; Rosa M Ortega; M Luisa Delgado-Losada; Ana M López-Parra; Aránzazu Aparicio Journal: Nutrients Date: 2020-03-23 Impact factor: 5.717