Sirwan K L Darweesh1, Silvan Licher1, Frank J Wolters2, Peter J Koudstaal3, M Kamran Ikram2, M Arfan Ikram4. 1. Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. 2. Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Neurology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. 3. Department of Neurology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. 4. Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. Electronic address: m.a.ikram@erasmusmc.nl.
Abstract
INTRODUCTION: Poor gait has recently emerged as a potential prodromal feature of cognitive decline and dementia. We assessed to what extent various aspects of poor gait are independently associated with cognitive decline and incident dementia. METHODS: We leveraged detailed quantitative gait (GAITRite™) and cognitive assessments in 4258 dementia-free participants (median age 67 years, 55% women) of the population-based Rotterdam Study (baseline 2009-2013). We summarized 30 gait parameters into seven mutually independent gait domains and a Global Gait score. Participants underwent follow-up cognitive assessments between 2014 and 2016 and were followed up for incident dementia until 2016 (median 4 years). RESULTS: Three independent gait domains (Base of Support, Pace, and Rhythm) and Global Gait were associated with cognitive decline. Two independent gait domains (Pace and Variability) and Global Gait were associated with incident dementia. Associations of gait with cognitive decline and incident dementia were only present in individuals who had been cognitively unimpaired at baseline. DISCUSSION: Poor performance on several independent gait domains precedes cognitive decline and incident dementia.
INTRODUCTION: Poor gait has recently emerged as a potential prodromal feature of cognitive decline and dementia. We assessed to what extent various aspects of poor gait are independently associated with cognitive decline and incident dementia. METHODS: We leveraged detailed quantitative gait (GAITRite™) and cognitive assessments in 4258 dementia-free participants (median age 67 years, 55% women) of the population-based Rotterdam Study (baseline 2009-2013). We summarized 30 gait parameters into seven mutually independent gait domains and a Global Gait score. Participants underwent follow-up cognitive assessments between 2014 and 2016 and were followed up for incident dementia until 2016 (median 4 years). RESULTS: Three independent gait domains (Base of Support, Pace, and Rhythm) and Global Gait were associated with cognitive decline. Two independent gait domains (Pace and Variability) and Global Gait were associated with incident dementia. Associations of gait with cognitive decline and incident dementia were only present in individuals who had been cognitively unimpaired at baseline. DISCUSSION: Poor performance on several independent gait domains precedes cognitive decline and incident dementia.
Authors: M Arfan Ikram; Guy Brusselle; Mohsen Ghanbari; André Goedegebure; M Kamran Ikram; Maryam Kavousi; Brenda C T Kieboom; Caroline C W Klaver; Robert J de Knegt; Annemarie I Luik; Tamar E C Nijsten; Robin P Peeters; Frank J A van Rooij; Bruno H Stricker; André G Uitterlinden; Meike W Vernooij; Trudy Voortman Journal: Eur J Epidemiol Date: 2020-05-04 Impact factor: 8.082
Authors: Marijn Muurling; Hanneke F M Rhodius-Meester; Juha Pärkkä; Mark van Gils; Kristian S Frederiksen; Marie Bruun; Steen G Hasselbalch; Hilkka Soininen; Sanna-Kaisa Herukka; Merja Hallikainen; Charlotte E Teunissen; Pieter Jelle Visser; Philip Scheltens; Wiesje M van der Flier; Jussi Mattila; Jyrki Lötjönen; Casper de Boer Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472
Authors: Kimberly D van der Willik; Silvan Licher; Elisabeth J Vinke; Maria J Knol; Sirwan K L Darweesh; Jos N van der Geest; Sanne B Schagen; M Kamran Ikram; Annemarie I Luik; M Arfan Ikram Journal: J Gerontol A Biol Sci Med Sci Date: 2021-01-18 Impact factor: 6.053