Literature DB >> 3151378

Light chain deposition disease presenting with hepatomegaly: an association with amyloid-like fibrils.

G Pelletier1, M Fabre, P Attali, A Ladouch-Badre, O Ink, E Martin, J P Etienne.   

Abstract

We report an unusual case of lambda light chain deposits without overt plasma cell dyscrasia. The clinical presentation was hepatomegaly without biochemical sign of renal involvement. Portal hypertension, spontaneous rupture of the spleen and fracture of the 12th thoracic vertebra occurred during the course of the disease. Ultrastructural studies showed that lambda light chain deposits were associated with amyloid-like deposits. This case suggests that light chain deposition disease and amyloidosis could be two expressions of the same disease.

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Year:  1988        PMID： 3151378      PMCID： PMC2428999          DOI： 10.1136/pgmj.64.756.804

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  9 in total

1.  Amyloid disease of the liver. Correlation of clinical, functional and morphologic features in forty-seven patients.

Authors:  R A LEVINE
Journal:  Am J Med       Date:  1962-09       Impact factor: 4.965

2.  Systemic kappa light chain deposition and amyloidosis in multiple myeloma: novel morphological observations.

Authors:  C J Kirkpatrick; A Curry; J Galle; I Melzner
Journal:  Histopathology       Date:  1986-10       Impact factor: 5.087

Review 3.  Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts).

Authors:  G G Glenner
Journal:  N Engl J Med       Date:  1980-06-05       Impact factor: 91.245

Review 4.  Manifestations of systemic light chain deposition.

Authors:  R E Randall; W C Williamson; F Mullinax; M Y Tung; W J Still
Journal:  Am J Med       Date:  1976-02       Impact factor: 4.965

5.  [Hepatic and renal deposits of kappa light chains revealing a dysglobulinemia (author's transl)].

Authors:  F Mignon; L Morel-Maroger; M Cerf; J L Preud'homme; G Richet
Journal:  Nephrologie       Date:  1980

6.  [Light chain deposit disease: an anatomopathological entity].

Authors:  C Hoffman-Guilaine; D Nochy; V Tricottet; L Mallet; J Bariety; J P Camilleri
Journal:  Ann Pathol       Date:  1984 Apr-May       Impact factor: 0.407

7.  Amyloidosis: review of 236 cases.

Authors:  R A Kyle; E D Bayrd
Journal:  Medicine (Baltimore)       Date:  1975-07       Impact factor: 1.889

8.  Light-chain glomerulopathy with amyloid-like deposits.

Authors:  C E Alpers; J Hopper; C G Biava
Journal:  Hum Pathol       Date:  1984-05       Impact factor: 3.466

9.  Liver involvement in nonamyloid light chain deposits disease.

Authors:  D Droz; L H Noel; F Carnot; F Degos; D Ganeval; J P Grunfeld
Journal:  Lab Invest       Date:  1984-06       Impact factor: 5.662
  9 in total
  5 in total

1.  Light chain deposition disease presenting as cholestatic jaundice: a case report.

Authors:  Prasanna N Kumar
Journal:  Oman Med J       Date:  2012-01

2.  Portal hypertension related to light chain deposition disease of liver: an enlightening experience.

Authors:  Arunansu Talukdar; Kabita Mukherjee; Dibbendhu Khanra; Manjari Saha
Journal:  BMJ Case Rep       Date:  2013-05-29

3.  Light chain deposition disease of the liver without renal involvement in a patient with multiple myeloma related to liver failure and rapid fatal outcome.

Authors:  Spyros Michopoulos; Kalliopi Petraki; Constantina Petraki; Meletios-Athanasios Dimopoulos
Journal:  Dig Dis Sci       Date:  2002-04       Impact factor: 3.199

4.  Light chain deposition disease of the kidney. Morphological aspects in 24 patients.

Authors:  E H Strøm; G B Fogazzi; G Banfi; C Pozzi; M J Mihatsch
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

5.  Systemic Reactive Amyloidosis Associated with Castleman's Disease.

Authors:  Vinaya Gaduputi; Hassan Tariq; Kanthi Badipatla; Ariyo Ihimoyan
Journal:  Case Rep Gastroenterol       Date:  2013-11-12
  5 in total

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