| Literature DB >> 31513413 |
Jun-Liang Zeng1,2, Yue Zhang1,2, Meng-Meng Zheng3, Zhi-Qi Zhang1,2, Xiao-Song Xue3, Fa-Guang Zhang1,2, Jun-An Ma1,2,3.
Abstract
We report a general and efficient approach to construct achiral and chiral gem-difluoroallylic amines from a masked difluorodiazo reagent (PhSO2CF2CHN2) and readily available imines. This facile protocol takes advantage of the phenylsulfonyl and diazo moieties as efficient activating and directing groups to assist difluoroalkyl incorporation and facilitate the chemodivergent and stereoselective formation of gem-difluoroallylic amines.Entities:
Year: 2019 PMID： 31513413 DOI： 10.1021/acs.orglett.9b02989
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005