| Literature DB >> 31508967 |
Zhenhua Liu1, Zhihai Zhang1, Guangyu Zhu1, Yiqin Zhou1, Lin Yang1, Wen Gao1, Lili Tong1, Bo Tang1.
Abstract
A novel and efficient aldol reaction of readily available vinyl azides with trifluoromethyl ketones by copper catalysis is developed. The reaction is proposed to go through a nucleophilic trapping of vinyl azides with trifluoromethyl ketones as a trifluoromethyl source, leading to the assembly of diverse trifluoromethylated compounds under mild conditions in satisfactory yield.Entities:
Year: 2019 PMID： 31508967 DOI： 10.1021/acs.orglett.9b02616
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005