| Literature DB >> 31507227 |
Do Thi Trang1, Duong Thi Hai Yen1, Nguyen The Cuong2, Luu The Anh3, Nguyen Thi Hoai4, Bui Huu Tai1,5, Vu Van Doan1, Pham Hai Yen1, Tran Hong Quang1, Nguyen Xuan Nhiem1,5, Chau Van Minh1, Phan Van Kiem1,5.
Abstract
Two new pregnane glycosides, gyminosides A and B (1 and 2) and three known, tinctoroside B (3), tinctoroside C (4), and gymnepregoside F (5) were isolated from the leaves of Gymnema inodorum (Lour.) Decne. Their structures were elucidated by physical and chemical methods and comparing with those reported in the literature. All these compounds were evaluated for α-glucosidase assay. Compound 5 exhibited the most anti α-glucosidase activity with inhibitory percentage of 63.7 ± 3.9% at the concentration of 200 μM. Compounds 1-4 showed moderate anti α-glucosidase activity with inhibitory percentage ranging from 40.0 to 52.1%.Entities:
Keywords: Asclepiadacaea; Gymnema inodorum; gyminoside; pregnane; α-glucosidase
Year: 2019 PMID： 31507227 DOI： 10.1080/14786419.2019.1663517
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861