Christian Tanislav1, Charles Christian Adarkwah2,3,4, Louis Jakob5, Karel Kostev6. 1. Department of Geriatrics, Diakonie Hospital Jung Stilling Siegen, Wichernstrasse 40, 57074, Siegen, Germany. christian.tanislav@diakonie-sw.de. 2. Department of Health Services Research and General Practice, Faculty of Life Sciences, University of Siegen, Siegen, Germany. 3. Department of General Practice and Family Medicine, Philipps-University, Marburg, Germany. 4. Department of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands. 5. Faculty of Medicine, University of Versailles Saint-Quentinen-Yvelines, Versailles, Montigny-le-Bretonneux, France. 6. Epidemiology, IQVIA, Frankfurt am Main, Germany.
Abstract
BACKGROUND: Etiological factors, such as a malignant disease, in young stroke patients are often neglected. Therefore, in this study, we aimed to investigate the risk of developing cancer in young stroke survivors. METHODS: The current case-control study sample included patients who received an initial ischemic stroke diagnosis documented in the Disease Analyzer database (IQVIA), which compiles data such as risk factors, drug prescriptions, and diagnoses obtained from general practitioners and specialists. RESULTS: The stroke and non-stroke groups included 18,668 patients each; each group had 2836 (15.3%) participants ≤ 55 years. The cancer incidence in the stroke group over the age of 55 years was higher than in the younger subgroup (29.4% versus 17.3%). The proportions of cancer patients within 10 years of follow-up were higher in the stroke group versus the non-stroke group, as well as in the subgroup of patients aged ≤ 55 versus patients > 55 years (17.3% versus 9.5% and 29.4% versus 24.9%, respectively). The calculated hazard ratio for developing cancer within 10 years of follow-up was higher in the younger stroke population (≤ 55 years) than in the older population (hazard ratio: 1.47 (CI 1.18-1.83) versus 1.17 (CI 1.10-1.25). CONCLUSION: In our cohort, young individuals aged ≤ 55 years who suffered a stroke had twice as high risk for developing cancer within 10 years after the index event compared to the control group. Stroke might have implication regarding the subsequent development of cancer and vice versa.
BACKGROUND: Etiological factors, such as a malignant disease, in young strokepatients are often neglected. Therefore, in this study, we aimed to investigate the risk of developing cancer in young stroke survivors. METHODS: The current case-control study sample included patients who received an initial ischemic stroke diagnosis documented in the Disease Analyzer database (IQVIA), which compiles data such as risk factors, drug prescriptions, and diagnoses obtained from general practitioners and specialists. RESULTS: The stroke and non-stroke groups included 18,668 patients each; each group had 2836 (15.3%) participants ≤ 55 years. The cancer incidence in the stroke group over the age of 55 years was higher than in the younger subgroup (29.4% versus 17.3%). The proportions of cancerpatients within 10 years of follow-up were higher in the stroke group versus the non-stroke group, as well as in the subgroup of patients aged ≤ 55 versus patients > 55 years (17.3% versus 9.5% and 29.4% versus 24.9%, respectively). The calculated hazard ratio for developing cancer within 10 years of follow-up was higher in the younger stroke population (≤ 55 years) than in the older population (hazard ratio: 1.47 (CI 1.18-1.83) versus 1.17 (CI 1.10-1.25). CONCLUSION: In our cohort, young individuals aged ≤ 55 years who suffered a stroke had twice as high risk for developing cancer within 10 years after the index event compared to the control group. Stroke might have implication regarding the subsequent development of cancer and vice versa.
Authors: Marc Carrier; Alejandro Lazo-Langner; Sudeep Shivakumar; Vicky Tagalakis; Ryan Zarychanski; Susan Solymoss; Nathalie Routhier; James Douketis; Kim Danovitch; Agnes Y Lee; Gregoire Le Gal; Philip S Wells; Daniel J Corsi; Timothy Ramsay; Doug Coyle; Isabelle Chagnon; Zahra Kassam; Hardy Tao; Marc A Rodger Journal: N Engl J Med Date: 2015-06-22 Impact factor: 91.245
Authors: Babak B Navi; Anne S Reiner; Hooman Kamel; Costantino Iadecola; Mitchell S V Elkind; Katherine S Panageas; Lisa M DeAngelis Journal: Ann Neurol Date: 2015-01-07 Impact factor: 10.422
Authors: A Piccioli; A W A Lensing; M H Prins; A Falanga; G L Scannapieco; M Ieran; M Cigolini; G B Ambrosio; M Monreal; A Girolami; P Prandoni Journal: J Thromb Haemost Date: 2004-06 Impact factor: 5.824
Authors: Brandi L Vollmer; Xing Chen; Erin R Kulick; Mitchell S V Elkind; Amelia K Boehme Journal: BMC Health Serv Res Date: 2021-01-22 Impact factor: 2.655