Literature DB >> 31504845

Microsurgical Resection of Brain Stem Ependymoma: 2-Dimensional Operative Video.

Mirza Pojskić1, Vincent Nguyen2, Goran Lakičević3, Kenan I Arnautović2,4.   

Abstract

The brainstem is a less-common location for ependymomas than the spinal cord where they are the most common adult intramedullary tumor.1-18 In this first video case report in the peer-reviewed literature, we demonstrate microsurgical resection of a medulla oblongata ependymoma.  There are several case reports of medulla oblongata ependymomas1,3,5,6,13 and a few series of spinal cord ependymomas that included cases of ependymomas of the cervicomedullary junction.9,10 The goal of surgery was to stabilize the preoperative neurological function; favorable outcome is achieved in patients with good preoperative statuses and well-defined tumor boundaries.9 Although gross total resection (GTR) provides the best overall outcome, it is most effective for classic grade II tumors, but not grade I (myxopapillary) and ependymomas, which have a lower GTR rate.14,15  A 55-yr-old patient developed 4-extremity weakness and dysphagia. Pre-/postcontrast magnetic resonance imaging (MRI) revealed centrally located brainstem lesion situated at the lower half of the medulla oblongata. Surgery, performed by the senior author, was performed in the prone position with a small suboccipital craniectomy and C1 posterior arch removal, followed by pia opening and posterior midline myelotomy. Tumor was debulked, dissected from the white matter, and resected. Histology revealed ependymoma (World Health Organization grade II). Postoperative pre-/postcontrast MRI revealed total resection. The patient's neurological deficit completely resolved postoperatively.  Written consent was obtained from the patient.
Copyright © Congress of Neurological Surgeons 2019.

Entities:  

Keywords:  Brain stem ependymoma; Brain stem tumor; Ependymoma; Medulla oblongata ependymoma; Microsurgical resection; Tumor

Mesh:

Year:  2020        PMID: 31504845      PMCID: PMC7594175          DOI: 10.1093/ons/opz252

Source DB:  PubMed          Journal:  Oper Neurosurg (Hagerstown)        ISSN: 2332-4252            Impact factor:   2.703


Disclosures

The authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article.
  18 in total

1.  [Microsurgery of cervical intramedullary ependymomas extending into the medulla oblongata].

Authors:  M Hoshimaru; T Koyama; N Hashimoto
Journal:  No Shinkei Geka       Date:  2000-06

2.  Signet-ring cell ependymoma with intratumoral hemorrhage in the medulla oblongata.

Authors:  Junichi Mizuno; Hiroshi Nakagawa; Tatsushi Inoue; Shiro Kondo; Kazuo Hara; Yoshio Hashizume
Journal:  J Clin Neurosci       Date:  2005-08       Impact factor: 1.961

3.  Surgical outcomes in spinal cord ependymomas and the importance of extent of resection in children and young adults.

Authors:  Michael Safaee; Michael C Oh; Praveen V Mummaneni; Philip R Weinstein; Christopher P Ames; Dean Chou; Mitchel S Berger; Andrew T Parsa; Nalin Gupta
Journal:  J Neurosurg Pediatr       Date:  2014-02-07       Impact factor: 2.375

Review 4.  Case of clear cell ependymoma of medulla oblongata: clinicopathological and immunohistochemical study with literature review.

Authors:  Vishwa Jeet Amatya; Yukio Takeshima; Mayumi Kaneko; Tomohiro Nakano; Satoshi Yamaguchi; Kazuhiko Sugiyama; Kaoru Kurisu; Yoichi Nakazato; Kouki Inai
Journal:  Pathol Int       Date:  2003-05       Impact factor: 2.534

5.  Laser-assisted microsurgical resection of thoracic intramedullary spinal cord ependymoma.

Authors:  James K Liu
Journal:  Neurosurg Focus       Date:  2012-07       Impact factor: 4.047

6.  Microsurgical resection of intramedullary spinal cord ependymoma.

Authors:  Paul C McCormick
Journal:  Neurosurg Focus       Date:  2014-09       Impact factor: 4.047

Review 7.  Prognosis by tumor location in adults with intracranial ependymomas.

Authors:  Eli T Sayegh; Derick Aranda; Joseph M Kim; Taemin Oh; Andrew T Parsa; Michael C Oh
Journal:  J Clin Neurosci       Date:  2014-07-15       Impact factor: 1.961

8.  A case of cervicomedullary junction tanycytic ependymoma associated with marked cyst formation.

Authors:  Tamio Ito; Yoshimaru Ozaki; Jyoji Nakagawara; Hirohiko Nakamura; Shinya Tanaka; Kazuo Nagashima
Journal:  Brain Tumor Pathol       Date:  2005       Impact factor: 3.298

9.  Spinal ependymomas: benefits of extent of resection for different histological grades.

Authors:  Michael C Oh; Phiroz E Tarapore; Joseph M Kim; Matthew Z Sun; Michael Safaee; Gurvinder Kaur; Derick M Aranda; Andrew T Parsa
Journal:  J Clin Neurosci       Date:  2013-06-12       Impact factor: 1.961

10.  Spinal ependymomas. Part 1: Intramedullary ependymomas.

Authors:  Jörg Klekamp
Journal:  Neurosurg Focus       Date:  2015-08       Impact factor: 4.047

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