| Literature DB >> 31504766 |
Diana Buitrago1, Laia Codó2, Ricard Illa1, Pau de Jorge1, Federica Battistini1, Oscar Flores1, Genis Bayarri1, Romina Royo2, Marc Del Pino2, Simon Heath3, Adam Hospital1, Josep Lluís Gelpí2,4, Isabelle Brun Heath1, Modesto Orozco1,4.
Abstract
We present Nucleosome Dynamics, a suite of programs integrated into a virtual research environment and created to define nucleosome architecture and dynamics from noisy experimental data. The package allows both the definition of nucleosome architectures and the detection of changes in nucleosomal organization due to changes in cellular conditions. Results are displayed in the context of genomic information thanks to different visualizers and browsers, allowing the user a holistic, multidimensional view of the genome/transcriptome. The package shows good performance for both locating equilibrium nucleosome architecture and nucleosome dynamics and provides abundant useful information in several test cases, where experimental data on nucleosome position (and for some cases expression level) have been collected for cells under different external conditions (cell cycle phase, yeast metabolic cycle progression, changes in nutrients or difference in MNase digestion level). Nucleosome Dynamics is a free software and is provided under several distribution models.Entities:
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Year: 2019 PMID： 31504766 PMCID： PMC6765203 DOI： 10.1093/nar/gkz759
Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971