Simulating imaging-based tomographic systems using optical design software for resolving 3D structures of translucent media.

Imaging-based tomography is emerging as the technique of choice for resolving 3D structures of translucent media, in particular for applications in external beam radiation therapy and combustion diagnostics. However, designing experimental prototypes is time-consuming and costly, and is carried out without the certainty of the imaging optics being optimal. In this paper, we present an optical-design-software-based method that enables end-to-end simulation imaging-based tomography systems. The method, developed using the real ray tracing features of Zemax OpticStudio, was validated in the context of 3D scintillation dosimetry, where multiple imaging systems are used to image the 3D light pattern emitted within an irradiated cubic plastic scintillator volume. The flexibility of the workflow enabled the assessment and comparison of the tomographic performance of standard and focused plenoptic cameras for the reconstruction of a clinical radiation dose distribution. The versatility of the proposed method offers the potential to ease the developmental and optimization process of imaging systems used in volumetric emission computed tomography applications.