Literature DB >> 31502136

Role of Neurotrophic Factors BDNF and GDNF in Nervous System Adaptation to the Influence of Ischemic Factors.

E V Mitroshina1, T A Mishchenko2, T V Shishkina2, M V Vedunova2.   

Abstract

We developed a complex in vitro model of ischemic damage. Analysis of hippocampal cell viability in primary cultures after modeling of various stress factors revealed the features of action of the main pathological factors of ischemia. Neurotrophic factors BDNF and GDNF produced pronounced neuroprotective effect during modeling both the complex ischemic damage and its individual pathophysiological components. Neurotrophic factor GDNF produced the most pronounced protective effect.

Entities:  

Keywords:  brain-derived neurotrophic factor; glial cell line-derived neurotrophic factor; ischemia; neuroprotection; primary nerve cell cultures

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Year:  2019        PMID： 31502136     DOI： 10.1007/s10517-019-04574-1

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  2 in total

1.  Estrogen-related Receptor α (ERRα) Functions in The Hypoxic Injury of Microglial Cells.

Authors:  Chao-Yang Deng; Ting-Ting Zhu; Shuai Lian; Jian-Fa Wang; Rui Wu; Jia-San Zheng
Journal:  J Vet Res       Date:  2022-03-10       Impact factor: 2.058

2.  The Influence of Neurotrophic Factors BDNF and GDNF Overexpression on the Functional State of Mice and Their Adaptation to Audiogenic Seizures.

Authors:  Angelina O Kustova; Maria S Gavrish; Marina A Sergeeva; Daria A Avlasenko; Anna O Kiseleva; Ekaterina A Epifanova; Alexey A Babaev; Tatiana A Mishchenko; Maria V Vedunova
Journal:  Brain Sci       Date:  2022-08-04
  2 in total

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