Literature DB >> 31502134

Role of Transcription Factor Oct4 in Postnatal Development and Function of the Adrenal Cortex.

N V Yaglova1, S S Obernikhin2, S V Nazimova2, V V Yaglov2.   

Abstract

We analyzed the expression of transcriptional factor Oct4 in rat adrenal cortical cells during postnatal development. It was found that Oct4 is expressed by typical cortical cells of the zona glomerulosa, zona fasciculata, and zona reticularis in pubertal and postpubertal periods. The maximum number of Oct4+ cells was found in the zona glomerulosa. An inverse correlation between the number of Oct4+ glomerulosa cells and serum level of aldosterone both in pubertal and postpubertal periods was revealed. After puberty, the number of Oct4+ glomerulosa cells directly correlated with the number of Ki-67+ cells. A hypothesis was put forward that Oct4 is involved in postnatal morphogenesis, regeneration, and functioning of the adrenal cortex.

Entities:  

Keywords:  Oct4; adrenal gland; pluripotency; postnatal development; proliferation

Mesh：

Substances：

Year:  2019        PMID： 31502134     DOI： 10.1007/s10517-019-04573-2

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  3 in total

1.  Low-Dose Exposure to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) Affects Transcriptional Regulation of Adrenal Zona Reticularis in Male Rats.

Authors:  N V Yaglova; S S Obernikhin; V V Yaglov; S V Nazimova; E P Timokhina; D A Tsomartova
Journal:  Bull Exp Biol Med       Date:  2021-03-31       Impact factor: 0.804

2.  Impaired Morphogenesis and Function of Rat Adrenal Zona Glomerulosa by Developmental Low-Dose Exposure to DDT Is Associated with Altered Oct4 Expression.

Authors:  Nataliya V Yaglova; Sergey S Obernikhin; Dibakhan A Tsomartova; Svetlana V Nazimova; Valentin V Yaglov; Elina S Tsomartova; Elizaveta V Chereshneva; Marina Y Ivanova; Tatiana A Lomanovskaya
Journal:  Int J Mol Sci       Date:  2021-06-12       Impact factor: 5.923

Review 3.  The Sexually Dimorphic Adrenal Cortex: Implications for Adrenal Disease.

Authors:  Rodanthi Lyraki; Andreas Schedl
Journal:  Int J Mol Sci       Date:  2021-05-05       Impact factor: 5.923
  3 in total

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