Diego Flores-Funes1, José Aguilar-Jiménez2, María Martínez-Gálvez3, María José Ibáñez-Ibáñez4, Luis Carrasco-González2, José Ignacio Gil-Izquierdo3, María Asunción Chaves-Benito5, Francisco Ayala-De La Peña6, Andrés Nieto-Olivares5, José Luis Aguayo-Albasini2. 1. General Surgery Department, Morales Meseguer University Hospital, Murcia, Spain; University of Murcia, Faculty of Medicine, IMIB-Arrixaca, "Mare Nostrum" International Excellence Campus, Murcia, Spain. Electronic address: diego.flores@um.es. 2. General Surgery Department, Morales Meseguer University Hospital, Murcia, Spain; University of Murcia, Faculty of Medicine, IMIB-Arrixaca, "Mare Nostrum" International Excellence Campus, Murcia, Spain. 3. Radiology Department, Morales Meseguer University Hospital, Murcia, Spain; University of Murcia, Faculty of Medicine, IMIB-Arrixaca, "Mare Nostrum" International Excellence Campus, Murcia, Spain. 4. Nuclear Medicine, Morales Meseguer University Hospital, Murcia, Spain; University of Murcia, Faculty of Medicine, IMIB-Arrixaca, "Mare Nostrum" International Excellence Campus, Murcia, Spain. 5. Pathology Department, Morales Meseguer University Hospital, Murcia, Spain; University of Murcia, Faculty of Medicine, IMIB-Arrixaca, "Mare Nostrum" International Excellence Campus, Murcia, Spain. 6. Hematology and Oncology Department, Morales Meseguer University Hospital, Murcia, Spain; University of Murcia, Faculty of Medicine, IMIB-Arrixaca, "Mare Nostrum" International Excellence Campus, Murcia, Spain.
Abstract
AIM: To study the feasibility and validity of ultrasound-guided pre-chemotherapy marking of metastatic axillary lymph nodes followed by targeted axillary dissection (TAD), in breast cancer patients undergoing neoadjuvant chemotherapy (NACT). MATERIAL AND METHOD: Prospective diagnostic test study conducted between January 2016 and March 2018. Patients with breast cancer and indication for NACT, cN1 or cN2 axillary staging, were included. A clip was placed in the affected lymph node prior to NACT. A sentinel lymph-node biopsy (SLNB) and a clipped lymph-node biopsy (BCLIP) were conducted, followed by axillary lymph node dissection (ALND). Location rate (LR) and negative predictive value (NPV) were evaluated, taking SLNB, BCLIP and their combination (TAD) as evaluated tests and metastatic involvement in the ALND specimen as the gold standard. RESULTS: Twenty-three patients were included in the study. Sentinel lymph node could only be detected in 19 cases (LR = 80.61%), whereas BCLIP was successful in 22 (LR = 95.65%). The sentinel lymph node coincided with the marked lymph node in 14 patients (60.9%). We found a NPV for the SLNB of 0.85 (95%CI: 0.61-1.0), whereas for TAD it was 1.00 (95%CI: 0.74-1.0). CONCLUSION: TAD is a feasible test for axillary restaging after NACT, with a higher success rate than SLNB.
AIM: To study the feasibility and validity of ultrasound-guided pre-chemotherapy marking of metastatic axillary lymph nodes followed by targeted axillary dissection (TAD), in breast cancerpatients undergoing neoadjuvant chemotherapy (NACT). MATERIAL AND METHOD: Prospective diagnostic test study conducted between January 2016 and March 2018. Patients with breast cancer and indication for NACT, cN1 or cN2 axillary staging, were included. A clip was placed in the affected lymph node prior to NACT. A sentinel lymph-node biopsy (SLNB) and a clipped lymph-node biopsy (BCLIP) were conducted, followed by axillary lymph node dissection (ALND). Location rate (LR) and negative predictive value (NPV) were evaluated, taking SLNB, BCLIP and their combination (TAD) as evaluated tests and metastatic involvement in the ALND specimen as the gold standard. RESULTS: Twenty-three patients were included in the study. Sentinel lymph node could only be detected in 19 cases (LR = 80.61%), whereas BCLIP was successful in 22 (LR = 95.65%). The sentinel lymph node coincided with the marked lymph node in 14 patients (60.9%). We found a NPV for the SLNB of 0.85 (95%CI: 0.61-1.0), whereas for TAD it was 1.00 (95%CI: 0.74-1.0). CONCLUSION: TAD is a feasible test for axillary restaging after NACT, with a higher success rate than SLNB.
Authors: Wolfram Malter; Christian Eichler; Bettina Hanstein; Peter Mallmann; Johannes Holtschmidt Journal: In Vivo Date: 2020 May-Jun Impact factor: 2.155
Authors: Patrik Pöschke; Julius Emons; Felix Heindl; Rüdiger Schulz-Wendtland; Sebastian Jud; Ramona Erber; Carolin C Hack; Caroline Preuss; Annika Behrens Journal: In Vivo Date: 2022 Sep-Oct Impact factor: 2.406
Authors: C S Pinto; B Peleteiro; C A Pinto; F Osório; S Costa; A Magalhães; H Mora; J Amaral; D Gonçalves; J L Fougo Journal: Breast Cancer Date: 2022-03-19 Impact factor: 3.307