| Literature DB >> 31499653 |
Wen Juan Guo1, Ming Ye2, Xi Ning Li1, Anke Meyer-Baese3, Qi Min Zhang1.
Abstract
This paper focuses on numerical approximation of the basic reproduction number R0, which is the threshold defined by the spectral radius of the next-generation operator in epidemiology. Generally speaking, R0 cannot be explicitly calculated for most age-structured epidemic systems. In this paper, for a deterministic age-structured epidemic system and its stochastic version, we discretize a linear operator produced by the infective population with a theta scheme in a finite horizon, which transforms the abstract problem into the problem of solving the positive dominant eigenvalue of the next-generation matrix. This leads to a corresponding threshold R0,n . Using the spectral approximation theory, we obtain that R0,n → R0 as n → +∞. Some numerical simulations are provided to certify the theoretical results.Keywords: Numerical approximation; age-structure epidemic system; basic reproduction number; spectral radius; theta scheme
Mesh:
Year: 2019 PMID: 31499653 DOI: 10.3934/mbe.2019204
Source DB: PubMed Journal: Math Biosci Eng ISSN: 1547-1063 Impact factor: 2.080