BACKGROUND: The management of locally advanced rectal cancer (RC) is an evolving clinical field where the multidisciplinary approach can reach its best, and liquid biopsy for obtaining tumor-derived component such as circulating tumor DNA (ctDNA) might provide complementary informations. METHODS: A systematic review of studies available in literature of liquid biopsy in non-metastatic RC has been performed according to PRISMA criteria to assess the role of ctDNA as a diagnostic, predictive and prognostic biomarker in this setting. RESULTS: Twenty-five publications have been retrieved, of which 8 full-text articles, 7 abstracts and 10 clinical trials. Results have been categorized into three groups: diagnostic, predictive and prognostic. Few but promising data are available about the use of liquid biopsy for early diagnosis of RC, with the main limitation of sensitivity due to low concentrations of ctDNA in this setting. In terms of prediction of response to chemoradiation, still inconclusive data are available about the utility of a pre-treatment liquid biopsy, whereas some studies report a positive correlation with a dynamic (pre/post-treatment) monitoring. The presence of minimal residual disease by ctDNA was consistently associated with worse prognosis across studies. CONCLUSIONS: The use of liquid biopsy for monitoring response to chemoradiation and assess the risk of disease recurrence are the most advanced potential applications for liquid biopsy in RC, with implications also in the context of non-operative management strategies.
BACKGROUND: The management of locally advanced rectal cancer (RC) is an evolving clinical field where the multidisciplinary approach can reach its best, and liquid biopsy for obtaining tumor-derived component such as circulating tumor DNA (ctDNA) might provide complementary informations. METHODS: A systematic review of studies available in literature of liquid biopsy in non-metastatic RC has been performed according to PRISMA criteria to assess the role of ctDNA as a diagnostic, predictive and prognostic biomarker in this setting. RESULTS: Twenty-five publications have been retrieved, of which 8 full-text articles, 7 abstracts and 10 clinical trials. Results have been categorized into three groups: diagnostic, predictive and prognostic. Few but promising data are available about the use of liquid biopsy for early diagnosis of RC, with the main limitation of sensitivity due to low concentrations of ctDNA in this setting. In terms of prediction of response to chemoradiation, still inconclusive data are available about the utility of a pre-treatment liquid biopsy, whereas some studies report a positive correlation with a dynamic (pre/post-treatment) monitoring. The presence of minimal residual disease by ctDNA was consistently associated with worse prognosis across studies. CONCLUSIONS: The use of liquid biopsy for monitoring response to chemoradiation and assess the risk of disease recurrence are the most advanced potential applications for liquid biopsy in RC, with implications also in the context of non-operative management strategies.
Authors: Gianluca Mauri; Pietro Paolo Vitiello; Alberto Sogari; Giovanni Crisafulli; Andrea Sartore-Bianchi; Silvia Marsoni; Salvatore Siena; Alberto Bardelli Journal: Br J Cancer Date: 2022-03-09 Impact factor: 9.075
Authors: Sarah Weber; Sebastian E Koschade; Christopher M Hoffmann; Taronish D Dubash; Klara M Giessler; Sebastian M Dieter; Friederike Herbst; Hanno Glimm; Claudia R Ball Journal: BMC Cancer Date: 2019-12-03 Impact factor: 4.430
Authors: Arvind Dasari; Van K Morris; Carmen J Allegra; Chloe Atreya; Al B Benson; Patrick Boland; Ki Chung; Mehmet S Copur; Ryan B Corcoran; Dustin A Deming; Andrea Dwyer; Maximilian Diehn; Cathy Eng; Thomas J George; Marc J Gollub; Rachel A Goodwin; Stanley R Hamilton; Jaclyn F Hechtman; Howard Hochster; Theodore S Hong; Federico Innocenti; Atif Iqbal; Samuel A Jacobs; Hagen F Kennecke; James J Lee; Christopher H Lieu; Heinz-Josef Lenz; O Wolf Lindwasser; Clara Montagut; Bruno Odisio; Fang-Shu Ou; Laura Porter; Kanwal Raghav; Deborah Schrag; Aaron J Scott; Qian Shi; John H Strickler; Alan Venook; Rona Yaeger; Greg Yothers; Y Nancy You; Jason A Zell; Scott Kopetz Journal: Nat Rev Clin Oncol Date: 2020-07-06 Impact factor: 65.011