Kendra J Kamp1, Kristen R Weaver2, LeeAnne B Sherwin3, Pamela Barney4, Sun-Kyung Hwang5, Pei-Lin Yang6, Robert L Burr7, Kevin C Cain8, Margaret M Heitkemper9. 1. University of Washington, United States of America. Electronic address: kamp@uw.edu. 2. University of Maryland, United States of America. Electronic address: kristen.weaver@umaryland.edu. 3. University of Missouri, United States of America. Electronic address: sherwinl@missouri.edu. 4. University of Washington, United States of America. Electronic address: pamb@uw.edu. 5. Pusan National University, South Korea. Electronic address: skhwang@uw.edu. 6. University of Washington, United States of America. Electronic address: plinyang@uw.edu. 7. University of Washington, United States of America. Electronic address: bobburr@uw.edu. 8. University of Washington, United States of America. Electronic address: cain@uw.edu. 9. University of Washington, United States of America. Electronic address: heit@uw.edu.
Abstract
OBJECTIVE:Adults with irritable bowel syndrome (IBS) often report extraintestinal pain, fatigue, and sleep disturbances in addition to abdominal pain. Few interventions have sought to reduce these extraintestinal symptoms within the IBS population. To address this, we compared the effects of a comprehensive self-management (CSM) intervention to a control intervention (usual care) on extraintestinal pain, fatigue, and sleep disturbances among patients with IBS. METHOD: Data were obtained from 243 IBS patients participating in two CSM intervention trials. Daily symptom diaries were collected at baseline, 3 and 6 months post-randomization. Daily symptoms of headache, backache, muscle pain, joint pain, fatigue, sleepiness during the day, sleep quality, and refreshed by sleep were analyzed. Analysis of covariance was used to determine the effects of the intervention on each symptom at 3 and 6 months controlling for 'study' and baseline symptom levels. RESULTS: Patients in the CSM intervention group reported decreased symptoms of fatigue, sleep disturbances, backache and headache compared to usual care at 3 and 6 months. The CSM group also reported significantly decreased joint pain at 3 months compared to usual care, but not 6 months. No significant difference was found for muscle pain. CONCLUSIONS: An existing CSM intervention is effective in reducing fatigue and sleep disturbances. However, mixed results for extraintestinal pain indicates a need to better differentiate between underlying mechanisms. Addressing such symptoms is important to decrease the overall burden of IBS, reduce health care expenditures, and improve patients' quality of life. TRIAL REGISTRATION: NCT00907790; NCT00167635.
RCT Entities:
OBJECTIVE: Adults with irritable bowel syndrome (IBS) often report extraintestinal pain, fatigue, and sleep disturbances in addition to abdominal pain. Few interventions have sought to reduce these extraintestinal symptoms within the IBS population. To address this, we compared the effects of a comprehensive self-management (CSM) intervention to a control intervention (usual care) on extraintestinal pain, fatigue, and sleep disturbances among patients with IBS. METHOD: Data were obtained from 243 IBSpatients participating in two CSM intervention trials. Daily symptom diaries were collected at baseline, 3 and 6 months post-randomization. Daily symptoms of headache, backache, muscle pain, joint pain, fatigue, sleepiness during the day, sleep quality, and refreshed by sleep were analyzed. Analysis of covariance was used to determine the effects of the intervention on each symptom at 3 and 6 months controlling for 'study' and baseline symptom levels. RESULTS:Patients in the CSM intervention group reported decreased symptoms of fatigue, sleep disturbances, backache and headache compared to usual care at 3 and 6 months. The CSM group also reported significantly decreased joint pain at 3 months compared to usual care, but not 6 months. No significant difference was found for muscle pain. CONCLUSIONS: An existing CSM intervention is effective in reducing fatigue and sleep disturbances. However, mixed results for extraintestinal pain indicates a need to better differentiate between underlying mechanisms. Addressing such symptoms is important to decrease the overall burden of IBS, reduce health care expenditures, and improve patients' quality of life. TRIAL REGISTRATION: NCT00907790; NCT00167635.
Authors: R L Levy; M Von Korff; W E Whitehead; P Stang; K Saunders; P Jhingran; V Barghout; A D Feld Journal: Am J Gastroenterol Date: 2001-11 Impact factor: 10.864
Authors: Monica E Jarrett; Kevin C Cain; Robert L Burr; Vicky L Hertig; Sheldon N Rosen; Margaret M Heitkemper Journal: Am J Gastroenterol Date: 2009-08-18 Impact factor: 10.864
Authors: Bruce D Naliboff; Minou Mayer; Ronnie Fass; Leah Z Fitzgerald; Lin Chang; Roger Bolus; Emeran A Mayer Journal: Psychosom Med Date: 2004 May-Jun Impact factor: 4.312
Authors: Monica E Jarrett; Kevin C Cain; Pamela G Barney; Robert L Burr; Bruce D Naliboff; Robert Shulman; Jasmine Zia; Margaret M Heitkemper Journal: J Neurogastroenterol Motil Date: 2016-01-31 Impact factor: 4.924
Authors: Pei-Lin Yang; Robert L Burr; Diana T Buchanan; Kenneth C Pike; Kendra J Kamp; Margaret M Heitkemper Journal: J Clin Sleep Med Date: 2020-10-15 Impact factor: 4.062
Authors: Edoardo Savarino; Fabiana Zingone; Brigida Barberio; Giovanni Marasco; Filiz Akyuz; Hale Akpinar; Oana Barboi; Giorgia Bodini; Serhat Bor; Giuseppe Chiarioni; Gheorghe Cristian; Maura Corsetti; Antonio Di Sabatino; Anca Mirela Dimitriu; Vasile Drug; Dan L Dumitrascu; Alexander C Ford; Goran Hauser; Radislav Nakov; Nisha Patel; Daniel Pohl; Cătălin Sfarti; Jordi Serra; Magnus Simrén; Alina Suciu; Jan Tack; Murat Toruner; Julian Walters; Cesare Cremon; Giovanni Barbara Journal: United European Gastroenterol J Date: 2022-06-13 Impact factor: 6.866
Authors: Pei-Lin Yang; Sarah W Matthews; Robert L Burr; Kevin C Cain; Pamela G Barney; Jasmine K Zia; Margaret H Heitkemper; Kendra J Kamp Journal: Int J Environ Res Public Health Date: 2022-03-04 Impact factor: 3.390