Ying Liu1, Xiaohua Peng2, Weizhen Weng3, Jianyun Zhu4, Hong Cao5, Shibin Xie6. 1. Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: liuy35@mail.sysu.edu.cn. 2. Digestive Medicine Institute, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. Electronic address: evelyn17@qq.com. 3. Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: usakiane@foxmail.com. 4. Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: 13719366255@139.com. 5. Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: billcaohong11@163.com. 6. Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: xieshibin1964@163.com.
Abstract
BACKGROUND: Ventriculoperitoneal (VP) shunting in cryptococcal meningitis (CM) patients with high intracranial pressure (ICP) has been studied extensively. METHODS: A total of 74 CM patients with ICP were identified, including 27 patients with or without ventriculomegaly receiving VP shunting. RESULTS: Through retrospective analysis, there was an obvious decline in ICP as well as Cryptococcus count after VP shunting. Damage to the cranial nerves was improved after the surgery. For those patients receiving VP shunting, there was an obvious decline in ICP as well as Cryptococcus count, with less usage of mannitol. Hydrocephalus or ventriculomegaly was improved, and both the clearance time of Cryptococcus and the hospitalization time were shortened (p<0.05). The complications of VP shunting were not common. CONCLUSIONS: For patients diagnosed with CM and with apparent ICP, VP shunting can be considered regardless of whether there is damage to the cranial nerves or hydrocephaly.
BACKGROUND: Ventriculoperitoneal (VP) shunting in cryptococcal meningitis (CM) patients with high intracranial pressure (ICP) has been studied extensively. METHODS: A total of 74 CMpatients with ICP were identified, including 27 patients with or without ventriculomegaly receiving VP shunting. RESULTS: Through retrospective analysis, there was an obvious decline in ICP as well as Cryptococcus count after VP shunting. Damage to the cranial nerves was improved after the surgery. For those patients receiving VP shunting, there was an obvious decline in ICP as well as Cryptococcus count, with less usage of mannitol. Hydrocephalus or ventriculomegaly was improved, and both the clearance time of Cryptococcus and the hospitalization time were shortened (p<0.05). The complications of VP shunting were not common. CONCLUSIONS: For patients diagnosed with CM and with apparent ICP, VP shunting can be considered regardless of whether there is damage to the cranial nerves or hydrocephaly.
Authors: Enock Kagimu; Nicole Engen; Kenneth Ssebambulidde; John Kasibante; Tadeo K Kiiza; Edward Mpoza; Lillian Tugume; Edwin Nuwagira; Laura Nsangi; Darlisha A Williams; Kathy Huppler Hullsiek; David R Boulware; David B Meya; Joshua Rhein; Mahsa Abassi; Abdu K Musubire Journal: Open Forum Infect Dis Date: 2022-08-17 Impact factor: 4.423