Aimilios Lallas1, Zoe Apalla2, Athanassios Kyrgidis3, Chryssoula Papageorgiou4, Ioannis Boukovinas5, Mattheos Bobos6, George Efthimiopoulos7, Christina Nikolaidou8, Andreas Moutsoudis4, Theodosia Gkentsidi4, Konstantinos Lallas4, Elizabeth Lazaridou9, Elena Sotiriou4, Efstratios Vakirlis4, Dimitrios Ioannides4. 1. First Department of Dermatology, Aristotle University, Thessaloniki, Greece. Electronic address: emlallas@gmail.com. 2. State Clinic of Dermatology, Hospital for Skin and Venereal Diseases, Thessaloniki, Greece. 3. Department of Clinical Pharmacology, Aristotle University, Thessaloniki, Greece. 4. First Department of Dermatology, Aristotle University, Thessaloniki, Greece. 5. Oncology Unit, Bioclinic of Thessaloniki, Thessaloniki, Greece. 6. Microdiagnostics Pathology Laboratory, Thessaloniki, Greece. 7. Department of Surgical Oncology, Theageneio Anticancer Hospital, Thessaloniki, Greece. 8. Department of Histopathology, Hippokration General Hospital, Thessaloniki, Greece. 9. Second Department of Dermatology, Aristotle University, Thessaloniki, Greece.
Abstract
BACKGROUND: In retrospective studies, a second primary melanoma (SPM) develops in 2%-20% of melanoma patients. Scarce evidence exists on the usefulness of total-body photography (TBP) and digital dermatoscopic documentation (DDD) for detecting SPMs. OBJECTIVE: The primary aim was to quantify the risk and investigate the time of occurrence of SPMs. Secondary aims were to identify risk factors for SPM and to assess the usefulness of TBP and DDD for SPM detection. METHODS: This prospective cohort included patients with recently diagnosed melanoma that underwent sequential clinical and dermatoscopic examinations for up to 5 years. Life table analysis and Kaplan-Meier survival analysis were performed. Multivariate Cox models were constructed to identify factors affecting the outcome. RESULTS: An SPM developed in 46 of 977 (4.7%) patients. Life table analysis revealed a 5-year cumulative risk of 8.0% for SPM. High nevus count, fair phototype, and occupational sun exposure were potent predictors of SPM. Of all new melanomas, 17.3% were diagnosed by clinical and dermatoscopic examination, 48.1% by TBP, and 34.6% by DDD. LIMITATIONS: All patients followed the same protocol and diagnostic bias associated with sequential dermatoscopic imaging. CONCLUSION: In this cohort, melanoma patients were at 8% risk of an SPM developing within 5 years. TBP and DDD significantly contributed to the early detection of SPM.
BACKGROUND: In retrospective studies, a second primary melanoma (SPM) develops in 2%-20% of melanomapatients. Scarce evidence exists on the usefulness of total-body photography (TBP) and digital dermatoscopic documentation (DDD) for detecting SPMs. OBJECTIVE: The primary aim was to quantify the risk and investigate the time of occurrence of SPMs. Secondary aims were to identify risk factors for SPM and to assess the usefulness of TBP and DDD for SPM detection. METHODS: This prospective cohort included patients with recently diagnosed melanoma that underwent sequential clinical and dermatoscopic examinations for up to 5 years. Life table analysis and Kaplan-Meier survival analysis were performed. Multivariate Cox models were constructed to identify factors affecting the outcome. RESULTS: An SPM developed in 46 of 977 (4.7%) patients. Life table analysis revealed a 5-year cumulative risk of 8.0% for SPM. High nevus count, fair phototype, and occupational sun exposure were potent predictors of SPM. Of all new melanomas, 17.3% were diagnosed by clinical and dermatoscopic examination, 48.1% by TBP, and 34.6% by DDD. LIMITATIONS: All patients followed the same protocol and diagnostic bias associated with sequential dermatoscopic imaging. CONCLUSION: In this cohort, melanomapatients were at 8% risk of an SPM developing within 5 years. TBP and DDD significantly contributed to the early detection of SPM.
Authors: Alyssa A Wiener; Jessica R Schumacher; Jennifer M Racz; Sharon M Weber; Yaohui G Xu; Heather B Neuman Journal: Ann Surg Oncol Date: 2022-05-03 Impact factor: 4.339
Authors: M Majem; J L Manzano; I Marquez-Rodas; K Mujika; E Muñoz-Couselo; E Pérez-Ruiz; L de la Cruz-Merino; E Espinosa; M Gonzalez-Cao; A Berrocal Journal: Clin Transl Oncol Date: 2021-03-02 Impact factor: 3.405