Alessandro de Sire1,2, Matteo Bigoni3, Lorenzo Priano3,4, Silvia Baudo3, Claudio Solaro1, Alessandro Mauro3,4. 1. Rehabilitation Unit, "Mons. L. Novarese" Hospital, Moncrivello, Vercelli, Italy. 2. Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont, Novara, Italy. 3. Istituto Auxologico Italiano, IRCCS, Department of Neurology and Neurorehabilitation S. Giuseppe Hospital, Piancavallo, Verbania, Italy. 4. Department of Neurosciences, University of Turin, Turin, Italy.
Abstract
BACKGROUND: There are few evidences on safety of Constraint-Induced Movement Therapy (CIMT), as well as its effects in neurological conditions, including multiple sclerosis (MS). OBJECTIVE: To evaluate safety and effectiveness of a 2-week CIMT protocol on upper limb activity of progressive MS patients through a three-dimensional (3D) kinematic analysis. METHODS: In this randomized single-blind pilot study, we randomly allocated patients affected by progressive MS reporting a reduced use of one upper limb into two different groups: CIMT group (less affected limb blocked by a splint) and control group (undergoing bi-manual treatment). Primary outcome was CIMT safety. Furthermore, we assessed CIMT effects through clinical outcomes (hand grip strength, HGS, and 9 Hole Peg Test, 9HPT) and 3D kinematic analysis (normalized jerk, number of movement units, going phase duration, mean velocity, endpoint error). All evaluations were performed at baseline (T0) and after 2 weeks of treatment (T1) for both arms in both groups. RESULTS:Ten MS patients, mean aged 51.0±7.7 years, were randomly allocated in the 2 groups. After treatment, no differences were found in the blocked arm. Furthermore, CIMT group showed significant improvements in clinical and kinematic parameters. CONCLUSIONS:CIMT might be considered a safe and effective technique in MS patients.
RCT Entities:
BACKGROUND: There are few evidences on safety of Constraint-Induced Movement Therapy (CIMT), as well as its effects in neurological conditions, including multiple sclerosis (MS). OBJECTIVE: To evaluate safety and effectiveness of a 2-week CIMT protocol on upper limb activity of progressive MSpatients through a three-dimensional (3D) kinematic analysis. METHODS: In this randomized single-blind pilot study, we randomly allocated patients affected by progressive MS reporting a reduced use of one upper limb into two different groups: CIMT group (less affected limb blocked by a splint) and control group (undergoing bi-manual treatment). Primary outcome was CIMT safety. Furthermore, we assessed CIMT effects through clinical outcomes (hand grip strength, HGS, and 9 Hole Peg Test, 9HPT) and 3D kinematic analysis (normalized jerk, number of movement units, going phase duration, mean velocity, endpoint error). All evaluations were performed at baseline (T0) and after 2 weeks of treatment (T1) for both arms in both groups. RESULTS: Ten MSpatients, mean aged 51.0±7.7 years, were randomly allocated in the 2 groups. After treatment, no differences were found in the blocked arm. Furthermore, CIMT group showed significant improvements in clinical and kinematic parameters. CONCLUSIONS: CIMT might be considered a safe and effective technique in MSpatients.
Authors: Dario Calafiore; Marco Invernizzi; Antonio Ammendolia; Nicola Marotta; Francesco Fortunato; Teresa Paolucci; Francesco Ferraro; Claudio Curci; Agnieszka Cwirlej-Sozanska; Alessandro de Sire Journal: Front Neurol Date: 2021-12-10 Impact factor: 4.003