Janet A Lydecker1, Ralitza Gueorguieva1,2, Robin Masheb1,3, Marney A White1,4, Carlos M Grilo1,5. 1. Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut. 2. Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut. 3. PRIME HSR&D Center of Innovation (COIN), VA Connecticut Healthcare System, West Haven, Connecticut. 4. Department of Social and Behavioral Sciences, Yale School of Public Health, New Haven, Connecticut. 5. Department of Psychology, Yale University, New Haven, Connecticut.
Abstract
OBJECTIVE: This study examined whether sex predicted and/or moderated treatment outcomes among men and women who participated in binge-eating disorder (BED) randomized controlled trials (RCTs). METHOD: Data were aggregated from RCTs performed at one medical center. RCTs tested cognitive-behavioral therapy, behavioral weight loss, multimodal treatment, and/or control conditions. Participants were 660 adults, both men (n = 170) and women (n = 490), with Diagnostic and Statistical Manual-fourth edition (DSM-IV)-defined BED. Doctoral-level research-clinicians assessed participants using structured interviews and established self-report measures of eating-disorder psychopathology and depression, and measured height and weight. Assessments occurred at baseline, throughout treatment, and at post-treatment. RESULTS: Sex was not a significant moderator of any treatment outcomes. Mixed models revealed sex had a main effect: men had lower eating-disorder psychopathology and lost more weight than women over the course of treatment. DISCUSSION: Both epidemiological and RCT studies report disparities in treatment-seeking between men and women with BED. Despite this, men have comparable or better treatment outcomes compared with women, including significantly greater weight loss. Thus, disseminating evidence-based BED treatments is promising for both men and women. Additional research is necessary, however, to understand treatment effects-including other predictors and moderators of outcomes-across diverse providers, treatment settings, and patient groups.
RCT Entities:
OBJECTIVE: This study examined whether sex predicted and/or moderated treatment outcomes among men and women who participated in binge-eating disorder (BED) randomized controlled trials (RCTs). METHOD: Data were aggregated from RCTs performed at one medical center. RCTs tested cognitive-behavioral therapy, behavioral weight loss, multimodal treatment, and/or control conditions. Participants were 660 adults, both men (n = 170) and women (n = 490), with Diagnostic and Statistical Manual-fourth edition (DSM-IV)-defined BED. Doctoral-level research-clinicians assessed participants using structured interviews and established self-report measures of eating-disorder psychopathology and depression, and measured height and weight. Assessments occurred at baseline, throughout treatment, and at post-treatment. RESULTS: Sex was not a significant moderator of any treatment outcomes. Mixed models revealed sex had a main effect: men had lower eating-disorder psychopathology and lost more weight than women over the course of treatment. DISCUSSION: Both epidemiological and RCT studies report disparities in treatment-seeking between men and women with BED. Despite this, men have comparable or better treatment outcomes compared with women, including significantly greater weight loss. Thus, disseminating evidence-based BED treatments is promising for both men and women. Additional research is necessary, however, to understand treatment effects-including other predictors and moderators of outcomes-across diverse providers, treatment settings, and patient groups.
Authors: Debra L Franko; Heather Thompson-Brenner; Douglas R Thompson; Christina L Boisseau; Angela Davis; Kelsie T Forbush; James P Roehrig; Susan W Bryson; Cynthia M Bulik; Scott J Crow; Michael J Devlin; Amy A Gorin; Carlos M Grilo; Jean L Kristeller; Robin M Masheb; James E Mitchell; Carol B Peterson; Debra L Safer; Ruth H Striegel; Denise E Wilfley; G Terence Wilson Journal: J Consult Clin Psychol Date: 2011-12-26
Authors: Thomas A Wadden; Delia S West; Rebecca H Neiberg; Rena R Wing; Donna H Ryan; Karen C Johnson; John P Foreyt; James O Hill; Dace L Trence; Mara Z Vitolins Journal: Obesity (Silver Spring) Date: 2009-01-29 Impact factor: 5.002
Authors: Angélica M Claudino; Irismar R de Oliveira; José Carlos Appolinario; Táki A Cordás; Monica Duchesne; Rosely Sichieri; Josué Bacaltchuk Journal: J Clin Psychiatry Date: 2007-09 Impact factor: 4.384
Authors: Denise E Wilfley; R Robinson Welch; Richard I Stein; Emily Borman Spurrell; Lisa R Cohen; Brian E Saelens; Jennifer Zoler Dounchis; Mary Ann Frank; Claire V Wiseman; Georg E Matt Journal: Arch Gen Psychiatry Date: 2002-08