OBJECTIVES: This meta-analysis aims to summarize and estimate the relationship between rheumatoid arthritis (RA) susceptibility and two polymorphisms of interleukin-17F (IL-17F) 7488A/G and 7383A/G. MATERIALS AND METHODS: PubMed, Embase and Web of Science were searched up to 01 July 2017. Case-control studies with genotype frequencies data for 7488A/G and 7383A/G were included. The pooled effects were calculated by fixed-effect model or random effects model. RESULTS: A total of seven publications with 1,409 RA patients and 1,303 controls were included in the present meta-analysis. The results indicated that 7488A/G was significantly associated with increased susceptibility to RA (GA vs. AA: odds ratio [OR]=1.43, 95% confidence interval [CI]: 1.07-1.90, p=0.02; GG vs. AA: OR=3.22, 95% CI: 1.54-6.74, p=0.002; GA+GG vs. AA: OR=1.57, 95% CI: 1.02-2.42, p=0.04; GG vs. GA+AA: OR=3.05, 95% CI: 1.46-6.39, p=0.003). In subgroup analysis, 7488A/G was a strong risk factor in Europeans but not in Americans or Africans. No significant association was found between 7383A/G and RA in overall population or ethnic subgroups by all genetic model comparisons. CONCLUSION: This meta-analysis provided evidence that IL-17F 7488A/G polymorphism is associated with increased RA susceptibility, while no clear correlation was found between 7383A/G and RA.
OBJECTIVES: This meta-analysis aims to summarize and estimate the relationship between rheumatoid arthritis (RA) susceptibility and two polymorphisms of interleukin-17F (IL-17F) 7488A/G and 7383A/G. MATERIALS AND METHODS: PubMed, Embase and Web of Science were searched up to 01 July 2017. Case-control studies with genotype frequencies data for 7488A/G and 7383A/G were included. The pooled effects were calculated by fixed-effect model or random effects model. RESULTS: A total of seven publications with 1,409 RA patients and 1,303 controls were included in the present meta-analysis. The results indicated that 7488A/G was significantly associated with increased susceptibility to RA (GA vs. AA: odds ratio [OR]=1.43, 95% confidence interval [CI]: 1.07-1.90, p=0.02; GG vs. AA: OR=3.22, 95% CI: 1.54-6.74, p=0.002; GA+GG vs. AA: OR=1.57, 95% CI: 1.02-2.42, p=0.04; GG vs. GA+AA: OR=3.05, 95% CI: 1.46-6.39, p=0.003). In subgroup analysis, 7488A/G was a strong risk factor in Europeans but not in Americans or Africans. No significant association was found between 7383A/G and RA in overall population or ethnic subgroups by all genetic model comparisons. CONCLUSION: This meta-analysis provided evidence that IL-17F 7488A/G polymorphism is associated with increased RA susceptibility, while no clear correlation was found between 7383A/G and RA.
Authors: S G Hymowitz; E H Filvaroff; J P Yin; J Lee; L Cai; P Risser; M Maruoka; W Mao; J Foster; R F Kelley; G Pan; A L Gurney; A M de Vos; M A Starovasnik Journal: EMBO J Date: 2001-10-01 Impact factor: 11.598
Authors: Matthew J Ruddy; Grace C Wong; Xikui K Liu; Hiroyasu Yamamoto; Soji Kasayama; Keith L Kirkwood; Sarah L Gaffen Journal: J Biol Chem Date: 2003-11-04 Impact factor: 5.157
Authors: Julia Seiderer; Ira Elben; Julia Diegelmann; Jürgen Glas; Johannes Stallhofer; Cornelia Tillack; Simone Pfennig; Matthias Jürgens; Silke Schmechel; Astrid Konrad; Burkhard Göke; Thomas Ochsenkühn; Bertram Müller-Myhsok; Peter Lohse; Stephan Brand Journal: Inflamm Bowel Dis Date: 2008-04 Impact factor: 5.325