Literature DB >> 3149734

Growth hormone regulation of growth hormone-releasing hormone gene expression.

V de Gennaro Colonna1, E Cattaneo, D Cocchi, E E Müller, A Maggi.   

Abstract

Slot-blot hybridization technique was used to evaluate growth hormone-releasing hormone (GHRH) mRNA levels in the hypothalamus of long-term (14 days) hypophysectomized (HPX) rats treated or not with 125 micrograms hGH/rat, twice daily IP, since the first day postsurgery. In addition, mRNA levels were determined in the hypothalamus of short-term (4 days) GH-treated (250 micrograms hGH/rat, twice daily IP) intact rats. GHRH mRNA levels were increased in HPX rats, and GH treatment partially counteracted this rise. Short-term administration of GH decreased GHRH mRNA levels in intact rats. These results, evaluated together with previous findings showing decreased hypothalamic GHRH-like immunoreactivity in both HPX rats and intact rats given GH (6, 7, 9), indicate that GH exerts a negative feedback action on the synthesis and release of GHRH.

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Year:  1988        PMID： 3149734     DOI： 10.1016/0196-9781(88)90077-0

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  4 in total

1.  Deficiency of growth hormone-releasing hormone signaling is associated with sleep alterations in the dwarf rat.

Authors:  F Obál; J Fang; P Taishi; B Kacsóh; J Gardi; J M Krueger
Journal:  J Neurosci       Date:  2001-04-15       Impact factor: 6.167

2.  Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons.

Authors:  D M Flavell; T Wells; S E Wells; D F Carmignac; G B Thomas; I C Robinson
Journal:  EMBO J       Date:  1996-08-01       Impact factor: 11.598

3.  The effects of a continuous infusion of hexarelin on pulsatile growth hormone release, growth axis and galanin gene expression and on the response of the growth axis to growth hormone-releasing hormone.

Authors:  L K Conley; R S Brogan; A Giustina; W B Wehrenberg
Journal:  Pituitary       Date:  2000-05       Impact factor: 4.107

4.  Chronic growth hormone (GH) hypersecretion induces reciprocal and reversible changes in mRNA levels from hypothalamic GH-releasing hormone and somatostatin neurons in the rat.

Authors:  J Bertherat; J Timsit; M T Bluet-Pajot; J J Mercadier; D Gourdji; C Kordon; J Epelbaum
Journal:  J Clin Invest       Date:  1993-04       Impact factor: 14.808
  4 in total

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