Chun-Yu Chen1,2, Ying-Hsuan Lee1, Shih-Hsin Chang1,3,4,5, Yung-Fong Tsai1,2, Jia-You Fang1,2,3,5, Tsong-Long Hwang1,2,3,5,6. 1. Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. 2. Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. 3. Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan. 4. Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. 5. Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. 6. Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243, Taiwan.
Abstract
AIM: This paper reports on the incorporation of oleic acid (OA) within nanostructured lipid carriers (OA-NLC) to improve the anti-inflammatory effects in the presence of albumin. MATERIALS AND METHODS: NLCs produced via hot high-shear homogenization/ultrasonication were characterized in terms of particle size, zeta potential, and toxicity. We examined the effects of OA-NLC on neutrophil activities. Dermatologic therapeutic potential was also elucidated by using a murine model of leukotriene B4-induced skin inflammation. RESULTS: In the presence of albumin, OA-NLC but not free OA inhibited superoxide generation and elastase release. Topical administration of OA-NLC alleviated neutrophil infiltration and severity of skin inflammation. CONCLUSION: OA incorporated within NLC can overcome the interference of albumin, which would undermine the anti-inflammatory effects of OA. OA-NLC has potential therapeutic effects in topical ointments.
AIM: This paper reports on the incorporation of oleic acid (OA) within nanostructured lipid carriers (OA-NLC) to improve the anti-inflammatory effects in the presence of albumin. MATERIALS AND METHODS: NLCs produced via hot high-shear homogenization/ultrasonication were characterized in terms of particle size, zeta potential, and toxicity. We examined the effects of OA-NLC on neutrophil activities. Dermatologic therapeutic potential was also elucidated by using a murine model of leukotriene B4-induced skin inflammation. RESULTS: In the presence of albumin, OA-NLC but not free OA inhibited superoxide generation and elastase release. Topical administration of OA-NLC alleviated neutrophil infiltration and severity of skin inflammation. CONCLUSION: OA incorporated within NLC can overcome the interference of albumin, which would undermine the anti-inflammatory effects of OA. OA-NLC has potential therapeutic effects in topical ointments.
Authors: S Terés; G Barceló-Coblijn; M Benet; R Alvarez; R Bressani; J E Halver; P V Escribá Journal: Proc Natl Acad Sci U S A Date: 2008-09-04 Impact factor: 11.205
Authors: Vishnu Hosur; Daniel A Skelly; Christopher Francis; Benjamin E Low; Vivek Kohar; Lisa M Burzenski; Mansoor M Amiji; Leonard D Shultz; Michael V Wiles Journal: Drug Discov Today Date: 2020-05-05 Impact factor: 7.851
Authors: Osama A A Ahmed; Usama A Fahmy; Rana Bakhaidar; Mohamed A El-Moselhy; Mohamed A Alfaleh; Al-Shaimaa F Ahmed; Asmaa S A Hammad; Hibah Aldawsari; Nabil A Alhakamy Journal: Int J Nanomedicine Date: 2020-04-15