| Literature DB >> 31496582 |
Mohamed Ibrahim Fahim1, Omaya Abdelhamid Nassar1, Osman Mohamed Mansour2, Abdelmaksoud Mohamed Ali1, Ahmed-Mostafa Mahmoud1, Nesreen Hassan Hafez3, Rasha Mahmoud Allam4, Amr Kamal1, Mohamed Ghareeb2.
Abstract
Treatment by cytoreductive surgery (CRS) and intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) has been an option for selected patients with peritoneal carcinomatosis. This study aims to evaluate the impact of HIPEC in epithelial ovarian cancer (EOC). A retrospective observational cohort study including 48 EOC patients treated and followed up between 2012 and 2016. Thirty-seven cases were treated by CRS only, while 11 cases were treated by CRS and HIPEC. The study was performed at National Cancer Institute (NCI)-Cairo University. There was no statistically significant difference regarding overall survival or disease-free survival between the group of EOC patients treated by CRS only and the one treated by CRS and HIPEC. Presence of ascites and histological types (serous/non-serous) were the significant independent variables related to overall survival. Presence of ascites was the only independent variable associated with a significant relation to disease-free survival. No statistically significant impact of HIPEC in treatment of EOC was found in this study.Entities:
Keywords: Cytoreductive surgery (CRS); Epithelial ovarian cancer (EOC); Hyperthermic intraperitoneal chemotherapy (HIPEC); Peritoneal cancer index (PCI); Peritoneal carcinomatosis
Year: 2019 PMID： 31496582 PMCID： PMC6708051 DOI： 10.1007/s13193-018-0867-y
Source DB: PubMed Journal: Indian J Surg Oncol ISSN： 0975-7651