Literature DB >> 3149562

G-proteins in the signal-transduction pathways of Dictyostelium discoideum.

B E Snaar-Jagalska1, F Kesbeke, P J Van Haastert.   

Abstract

The functional interaction of surface cAMP receptors with effector enzymes via G-proteins was investigated in Dictyostelium discoideum. Several experimental conditions were used to investigate signal transduction, such as reduced temperatures, use of down-regulated cells and of mutants. The results are presented as a model describing the complex interaction between multiple forms of the surface cAMP receptor and different G-proteins that are responsible for the generation of the second messengers, cAMP, cGMP, InsP3 and Ca2+.

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Year:  1988        PMID： 3149562     DOI： 10.1002/dvg.1020090404

Source DB:  PubMed          Journal:  Dev Genet        ISSN： 0192-253X


  9 in total

Review 1.  Genetic networks that regulate development in Dictyostelium cells.

Authors:  W F Loomis
Journal:  Microbiol Rev       Date:  1996-03

2.  The Dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase.

Authors:  H Ma; M Gamper; C Parent; R A Firtel
Journal:  EMBO J       Date:  1997-07-16       Impact factor: 11.598

3.  Cloning and targeted mutations of G alpha 7 and G alpha 8, two developmentally regulated G protein alpha-subunit genes in Dictyostelium.

Authors:  L Wu; C Gaskins; K Zhou; R A Firtel; P N Devreotes
Journal:  Mol Biol Cell       Date:  1994-06       Impact factor: 4.138

4.  Dual role of cAMP and involvement of both G-proteins and ras in regulation of ERK2 in Dictyostelium discoideum.

Authors:  M L Knetsch; S J Epskamp; P W Schenk; Y Wang; J E Segall; B E Snaar-Jagalska
Journal:  EMBO J       Date:  1996-07-01       Impact factor: 11.598

5.  Selective induction of gene expression and second-messenger accumulation in Dictyostelium discoideum by the partial chemotactic antagonist 8-p-chlorophenylthioadenosine 3',5'-cyclic monophosphate.

Authors:  D J Peters; A A Bominaar; B E Snaar-Jagalska; R Brandt; P J Van Haastert; A Ceccarelli; J G Williams; P Schaap
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205

6.  The surface cyclic AMP receptors, cAR1, cAR2, and cAR3, promote Ca2+ influx in Dictyostelium discoideum by a G alpha 2-independent mechanism.

Authors:  J L Milne; P N Devreotes
Journal:  Mol Biol Cell       Date:  1993-03       Impact factor: 4.138

7.  Dictyostelium discoideum lipids modulate cell-cell cohesion and cyclic AMP signaling.

Authors:  D R Fontana; C S Luo; J C Phillips
Journal:  Mol Cell Biol       Date:  1991-01       Impact factor: 4.272

8.  cAMP-mediated inhibition of intracellular particle movement and actin reorganization in Dictyostelium.

Authors:  D Wessels; N A Schroeder; E Voss; A L Hall; J Condeelis; D R Soll
Journal:  J Cell Biol       Date:  1989-12       Impact factor: 10.539

9.  A density-sensing factor regulates signal transduction in Dictyostelium.

Authors:  I S Yuen; R Jain; J D Bishop; D F Lindsey; W J Deery; P J Van Haastert; R H Gomer
Journal:  J Cell Biol       Date:  1995-06       Impact factor: 10.539
  9 in total

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