Naushad Ahmad Khan 1 , Gina Lawyer 1 , Samantha McDonough 1 , Qixin Wang 1 , Noura O Kassem 2 , Flora Kas-Petrus 2 , Dongxia Ye 1 , Kameshwar P Singh 1 , Nada Of Kassem 2 , Irfan Rahman 3 Show Affiliations »
Abstract
BACKGROUND: Waterpipe tobacco (WPT) smoking is associated with deleterious effects on cardio-pulmonary systems which may have adverse repercussions in pathophysiology and progression of chronic lung and cardiovascular diseases. We compared the biomarkers of systemic inflammation, lipid mediators, injury/repair and oxidative stress between groups of non-smokers (NS), exclusive WPT smokers (WPS), exclusive cigarette smokers (CS) and dual WPS and CS (DS). METHODS: Two cohorts were recruited. Cohort I consisted of WPS (n=12), CS (n=26), DS (n=10) and NS (n=25). Cohort II consisted of WPS (n=33) and NS (n=24). Plasma and urine samples were collected and analysed for various systemic biomarkers. RESULTS: Compared with NS, plasma levels of inflammatory mediators (interleukin (IL)-6, IL-8, IL1β and tumor necrosis factor-α) were significantly higher in WPS and CS, and were further augmented in DS. Endothelial biomarkers (intracellular adhesion molecule-1, prostaglandin E-2 and metalloproteinase-9) were significantly higher in CS. Most notably, pro-resolving lipid mediator (resolvin E1) and biomarkers of immunity, tissue injury, and repair were significantly lower in WPS and CS. Urinary levels of 8-isoprostane were significantly higher in all smoking groups in cohort I, while 8-isoprostane, myeloperoxidase, receptor for advanced glycation end products (RAGE), En-RAGE and matrix metalloproteinase-9 were significantly higher in all smoking groups in cohort II. CONCLUSIONS: Biomarkers of inflammation, oxidative stress, immunity, tissue injury and repair were elevated in WPS and CS groups. Furthermore, concurrent use of WPT and cigarettes is more harmful than cigarette or WPT smoking alone. These data may help inform the public and policy-makers about the dangers of WPT smoking and dual use of tobacco products. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
BACKGROUND: Waterpipe tobacco (WPT) smoking is associated with deleterious effects on cardio-pulmonary systems which may have adverse repercussions in pathophysiology and progression of chronic lung and cardiovascular diseases . We compared the biomarkers of systemic inflammation , lipid mediators, injury /repair and oxidative stress between groups of non-smokers (NS), exclusive WPT smokers (WPS ), exclusive cigarette smokers (CS ) and dual WPS and CS (DS ). METHODS: Two cohorts were recruited. Cohort I consisted of WPS (n=12), CS (n=26), DS (n=10) and NS (n=25). Cohort II consisted of WPS (n=33) and NS (n=24). Plasma and urine samples were collected and analysed for various systemic biomarkers. RESULTS: Compared with NS, plasma levels of inflammatory mediators (interleukin (IL)-6 , IL-8 , IL1β and tumor necrosis factor-α) were significantly higher in WPS and CS , and were further augmented in DS . Endothelial biomarkers (intracellular adhesion molecule-1, prostaglandin E-2 and metalloproteinase-9 ) were significantly higher in CS . Most notably, pro-resolving lipid mediator (resolvin E1 ) and biomarkers of immunity, tissue injury , and repair were significantly lower in WPS and CS . Urinary levels of 8-isoprostane were significantly higher in all smoking groups in cohort I, while 8-isoprostane , myeloperoxidase , receptor for advanced glycation end products (RAGE), En-RAGE and matrix metalloproteinase-9 were significantly higher in all smoking groups in cohort II. CONCLUSIONS: Biomarkers of inflammation , oxidative stress, immunity, tissue injury and repair were elevated in WPS and CS groups. Furthermore, concurrent use of WPT and cigarettes is more harmful than cigarette or WPT smoking alone. These data may help inform the public and policy-makers about the dangers of WPT smoking and dual use of tobacco products. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Entities: Chemical
Disease
Gene
Species
Keywords:
biomarkers; cigarette smokers; hookah; inflammation; oxidative stress; waterpipe
Mesh： See more »
Substances： See more »
Year: 2019
PMID： 31494573 PMCID： PMC7050420 DOI： 10.1136/tobaccocontrol-2019-054958
Source DB: PubMed Journal: Tob Control ISSN： 0964-4563 Impact factor: 7.552