Temperature Monitorable Kinetics Study of Human Blood Coagulation by Utilizing a Dual-Mode AlN-Based Acoustic Wave Resonator.

In this study, we reported an acoustic wave resonator for temperature monitorable kinetic analysis of human blood coagulation. The resonator is operated in both Lamb wave mode at 860 MHz and Rayleigh wave mode at 444 MHz. The electrical parameter variation of the resonator induced by the increased plasma viscosity can be used to monitor the coagulation process. The Lamb mode of the resonator is sensitive to both plasma viscosity and plasma temperature, while the Rayleigh mode responds only to the temperature which is not affected by viscosity. These unique characteristics of the two modes are due to different spatial distributions of the acoustic energy. Taking advantage of the aforementioned features, an acoustic wave resonator to study the human blood coagulation is designed to simultaneously monitor the temperature and plasma viscosity. The coagulation time and plasma temperature were provided by fitting the time-frequency curves. Our design holds great promise for biological reaction monitoring with possible temperature changes.