Sadeq Ali Al-Maweri1,2, Esam Halboub3, Ghadah Al-Sufyani4, Ahmed Yaseen Alqutaibi5, Anas Shamala6, Anas Alsalhani1. 1. Department of Oral Medicine and Diagnostic Sciences, AlFarabi Colleges of Dentistry and Nursing, Riyadh, Saudi Arabia. 2. Department of Oral Medicine, Faculty of Dentistry, Sana'a University, Sana'a, Yemen. 3. Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia. 4. Private Dental center, Sana'a, Yemen. 5. College of Dentistry, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia. 6. Department of Biological and Preventive Sciences, College of Dentistry, University of Sciences and Technology, Sana'a, Yemen.
Abstract
OBJECTIVES: A few studies have associated vitamin D deficiency with the occurrence of recurrent aphthous stomatitis (RAS). Hence, the aim of the present systematic review and meta-analysis is to explore such a potential association. METHODS: A comprehensive search of PubMed, Scopus, and Web of Science databases was conducted in June 2019. The inclusion criteria were (a) observational studies that assessed the relationship between vitamin D and RAS, and (b) the outcome measures reported quantitative vitamin D levels. Studies without control groups, case series, case reports, experimental studies, letter to editors, reviews, were excluded. The random effects model was conducted for meta-analyses using RevMan 5.3 software. RESULTS: Five studies comprising 208 RAS patients and 241 healthy individuals were included. All studies except one reported significantly lower levels of vitamin D in RAS patients compared with the healthy individuals. The results of the pooled 5 studies revealed statistically significant lower levels of vitamin D in RAS patients (Mean Difference (MD) = -9.67 ng/ml, 95% CI = -15.68, -3.65; p ˂ .002). CONCLUSION: The present meta-analysis suggests a significant association between low vitamin D levels and RAS. Further well-designed studies with adequate sample sizes are required to elucidate the role of vitamin D in pathogenesis of RAS.
OBJECTIVES: A few studies have associated vitamin D deficiency with the occurrence of recurrent aphthous stomatitis (RAS). Hence, the aim of the present systematic review and meta-analysis is to explore such a potential association. METHODS: A comprehensive search of PubMed, Scopus, and Web of Science databases was conducted in June 2019. The inclusion criteria were (a) observational studies that assessed the relationship between vitamin D and RAS, and (b) the outcome measures reported quantitative vitamin D levels. Studies without control groups, case series, case reports, experimental studies, letter to editors, reviews, were excluded. The random effects model was conducted for meta-analyses using RevMan 5.3 software. RESULTS: Five studies comprising 208 RAS patients and 241 healthy individuals were included. All studies except one reported significantly lower levels of vitamin D in RAS patients compared with the healthy individuals. The results of the pooled 5 studies revealed statistically significant lower levels of vitamin D in RAS patients (Mean Difference (MD) = -9.67 ng/ml, 95% CI = -15.68, -3.65; p ˂ .002). CONCLUSION: The present meta-analysis suggests a significant association between low vitamin D levels and RAS. Further well-designed studies with adequate sample sizes are required to elucidate the role of vitamin D in pathogenesis of RAS.
Authors: Sadeq Ali Al-Maweri; Esam Halboub; Sajna Ashraf; Ahmed Y Alqutaibi; Nashwan Mohammed Qaid; Kamila Yahya; Mohammed Nasser Alhajj Journal: BMC Oral Health Date: 2020-08-24 Impact factor: 2.757
Authors: Kaiyuan Xu; Chongchong Zhou; Fan Huang; Ning Duan; Yanyi Wang; Lichun Zheng; Xiang Wang; Wenmei Wang Journal: J Int Med Res Date: 2021-05 Impact factor: 1.671