| Literature DB >> 31493258 |
E V Stelmashook1, E E Genrikhs1, E V Mukhaleva1,2, M R Kapkaeva1, R V Kondratenko1, V G Skrebitsky1, N K Isaev3,4.
Abstract
Focal unilateral traumatic brain injury in the sensorimotor cortical region disturbed the functions of contralateral limbs controlled by the damaged hemisphere. A single intravenous injection of methylene blue (1 mg/kg) immediately before or 30 min after the injury significantly weakened functional disorders in the affected extremities. In vitro experiments showed that methylene blue effectively reduced death of cultured neurons provoked by paraquat or zinc ions producing the toxic effects on mitochondrias.Entities:
Keywords: methylene blue; neurons; paraquat; traumatic brain injury; zinc ions
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Year: 2019 PMID： 31493258 DOI： 10.1007/s10517-019-04548-3
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804