| Literature DB >> 31493226 |
Andrea Ticinesi1,2, Antonio Nouvenne3,4, Claudio Tana3, Beatrice Prati3, Tiziana Meschi3,4,5.
Abstract
Gut microbiota composition and functionality can influence the pathophysiology of age-related cognitive impairment and dementia, according to a large number of animal studies. The translation of this concept to humans is still uncertain, due to the relatively low number of clinical studies focused on fecal microbiota and large number of environmental factors that influence the microbiota composition. However, the fecal microbiota composition of older patients with dementia is deeply different from that of healthy active controls, conditioning a different metabolic profile. The possible use of fecal microbiota-related parameters and microbiota-derived metabolites as biomarkers of cognitive performance and dementia is critically reviewed in this paper, focusing on the most promising areas of research for the future.Entities:
Keywords: Alzheimer’s disease; Biodiversity; Firmicutes/Bacteroidetes ratio; Microbial metabolites; Mild cognitive impairment
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Year: 2019 PMID： 31493226 DOI： 10.1007/978-3-030-25650-0_8
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622